Liviu C. Ciobanu, Ph.D.

2003 Universite Laval (Canada) 
Pharmaceutical Chemistry
"Liviu Ciobanu"
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Donald Poirier grad student 2003 Universite Laval (Canada)
 (Synthese chimique en solution et sur support solide d'inhibiteurs de la steroide sulfatase.)
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Cantin L, Faucher FR, Couture JF, et al. (2007) Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12 Journal of Biological Chemistry. 282: 30910-30919
Ciobanu LC, Poirier D. (2006) Synthesis of libraries of 16beta-aminopropyl estradiol derivatives for targeting two key steroidogenic enzymes. Chemmedchem. 1: 1249-59
Maltais R, Tremblay MR, Ciobanu LC, et al. (2004) Steroids and combinatorial chemistry. Journal of Combinatorial Chemistry. 6: 443-56
Ciobanu LC, Luu-The V, Martel C, et al. (2003) Inhibition of estrone sulfate-induced uterine growth by potent nonestrogenic steroidal inhibitors of steroid sulfatase. Cancer Research. 63: 6442-6
Ciobanu LC, Poirier D. (2003) Solid-phase parallel synthesis of 17alpha-substituted estradiol sulfamate and phenol libraries using the multidetachable sulfamate linker. Journal of Combinatorial Chemistry. 5: 429-40
Ciobanu LC, Boivin RP, Luu-The V, et al. (2003) 3Beta-sulfamate derivatives of C19 and C21 steroids bearing a t-butylbenzyl or a benzyl group: synthesis and evaluation as non-estrogenic and non-androgenic steroid sulfatase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 18: 15-26
Poirier D, Ciobanu LC, Bérubé M. (2002) A multidetachable sulfamate linker successfully used in a solid-phase strategy to generate libraries of sulfamate and phenol derivatives. Bioorganic & Medicinal Chemistry Letters. 12: 2833-8
Ciobanu LC, Luu-The V, Poirier D. (2002) Nonsteroidal compounds designed to mimic potent steroid sulfatase inhibitors. The Journal of Steroid Biochemistry and Molecular Biology. 80: 339-53
Ciobanu LC, Boivin RP, Luu-The V, et al. (2001) Synthesis and steroid sulphatase inhibitory activity of C19- and C21-steroidal derivatives bearing a benzyl-inhibiting group. European Journal of Medicinal Chemistry. 36: 659-71
Ciobanu LC, Maltais R, Poirier D. (2000) The sulfamate functional group as a new anchor for solid-phase organic synthesis Organic Letters. 2: 445-8
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