Nica M. Borradaile, Ph.D.

Affiliations: 
2003 The University of Western Ontario (Canada) 
Area:
Biochemistry, Nutrition
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"Nica Borradaile"
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Murray W. Huff grad student 2003 The University of Western Ontario (Canada)
 (Regulation of hepatocyte apolipoprotein B metabolism by citrus and soy flavonoids.)
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Publications

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Peters KM, Zhang R, Park C, et al. (2019) Vitamin D intervention does not improve vascular regeneration in diet-induced obese male mice with peripheral ischemia. The Journal of Nutritional Biochemistry. 70: 65-74
Hetherington AM, Sawyez CG, Borradaile NM. (2017) Microarray data and pathway analyses for primary human activated hepatic stellate cells compared to HepG2 human hepatoma cells. Data in Brief. 10: 385-389
Hetherington AM, Sawyez CG, Zilberman E, et al. (2016) Differential Lipotoxic Effects of Palmitate and Oleate in Activated Human Hepatic Stellate Cells and Epithelial Hepatoma Cells. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 39: 1648-1662
Hetherington AM, Sawyez CG, Sutherland BG, et al. (2016) Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice. Physiological Reports. 4
Pang DK, Nong Z, Sutherland BG, et al. (2016) Niacin promotes revascularization and recovery of limb function in diet-induced obese mice with peripheral ischemia. Pharmacology Research & Perspectives. 4: e00233
Stoianov AM, Robson DL, Hetherington AM, et al. (2015) Elongation Factor 1A-1 Is a Mediator of Hepatocyte Lipotoxicity Partly through Its Canonical Function in Protein Synthesis. Plos One. 10: e0131269
Allister EM, Borradaile NM, Edwards JY, et al. (2005) Inhibition of microsomal triglyceride transfer protein expression and apolipoprotein B100 secretion by the citrus flavonoid naringenin and by insulin involves activation of the mitogen-activated protein kinase pathway in hepatocytes. Diabetes. 54: 1676-83
Borradaile NM, de Dreu LE, Huff MW. (2003) Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation. Diabetes. 52: 2554-61
Borradaile NM, de Dreu LE, Barrett PH, et al. (2003) Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation. Biochemistry. 42: 1283-91
Borradaile NM, de Dreu LE, Barrett PH, et al. (2002) Inhibition of hepatocyte apoB secretion by naringenin: enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters. Journal of Lipid Research. 43: 1544-54
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