Gavin MacBeath, PhD

Affiliations: 
Chemistry and Chemical Biology Harvard University, Cambridge, MA, United States 
Area:
Protein Systems
Website:
http://macbeath.hms.harvard.edu/
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"Gavin MacBeath"
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SNBCP

Parents

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Donald M. Hilvert grad student 1997 Scripps Institute
 (Evolutionary Approaches to the Design of Protein Receptors and Catalysts)
Stuart L. Schreiber post-doc 2001 Harvard

Children

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Jiunn-Ren Chen grad student 2008 Harvard
Andrew G. Gordus grad student 2008 Harvard
Michael A. Stiffler grad student 2008 Harvard
Tanya L. Knickerbocker grad student 2009 Harvard
Jordan A. Krall grad student 2009 Harvard
Elsa M. Beyer grad student 2010 Harvard
Ethan S. Karp grad student 2010 Harvard
Alexis L. Kaushansky grad student 2010 Harvard
Grigoriy Koytiger grad student 2013 Harvard
Albert S. Ye grad student 2013 Harvard
Richard Baker Jones post-doc 2002-2006 Harvard
BETA: Related publications

Publications

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Curley MD, Sabnis GJ, Wille L, et al. (2015) Seribantumab, an anti-ERBB3 antibody, delays the onset of resistance and restores sensitivity to letrozole in an estrogen receptor-positive breast cancer model. Molecular Cancer Therapeutics
Qian G, Jiang N, Wang D, et al. (2015) Heregulin and HER3 are prognostic biomarkers in oropharyngeal squamous cell carcinoma. Cancer
Yarar D, Lahdenranta J, Kubasek W, et al. (2015) Heregulin-ErbB3-Driven Tumor Growth Persists in PI3 Kinase Mutant Cancer Cells. Molecular Cancer Therapeutics
Gujral TS, Chan M, Peshkin L, et al. (2014) A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell. 159: 844-56
AlQuraishi M, Koytiger G, Jenney A, et al. (2014) A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks. Nature Genetics. 46: 1363-71
Yi CR, Allen JE, Russo B, et al. (2014) Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins. The Journal of Biological Chemistry. 289: 30101-13
Jiang N, Wang D, Hu Z, et al. (2014) Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma. Molecular Cancer Therapeutics. 13: 1826-36
Onsum MD, Geretti E, Paragas V, et al. (2013) Single-cell quantitative HER2 measurement identifies heterogeneity and distinct subgroups within traditionally defined HER2-positive patients. The American Journal of Pathology. 183: 1446-60
Wagner JP, Wolf-Yadlin A, Sevecka M, et al. (2013) Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks. Science Signaling. 6: ra58
Gujral TS, Karp ES, Chan M, et al. (2013) Family-wide investigation of PDZ domain-mediated protein-protein interactions implicates β-catenin in maintaining the integrity of tight junctions. Chemistry & Biology. 20: 816-27
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