Todd Macfarlan, Ph.D.

Affiliations: 
2005 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Molecular Biology, Cell Biology
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"Todd Macfarlan"
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Debabrata Chakravarti grad student 2005 Penn
 (Identification and initial characterization of thanatos associated protein 7 (THAP7), a putative transcriptional repressor.)
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Loomis RJ, Naoe Y, Parker JB, et al. (2009) Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation. Molecular Cell. 33: 450-61
Macfarlan T, Parker JB, Nagata K, et al. (2006) Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription. Molecular Endocrinology (Baltimore, Md.). 20: 335-47
Macfarlan T, Kutney S, Altman B, et al. (2005) Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor. The Journal of Biological Chemistry. 280: 7346-58
Hong R, Macfarlan T, Kutney SN, et al. (2004) The identification of phosphorylation sites of pp32 and biochemical purification of a cellular pp32-kinase. Biochemistry. 43: 10157-65
Kutney SN, Hong R, Macfarlan T, et al. (2004) A signaling role of histone-binding proteins and INHAT subunits pp32 and Set/TAF-Ibeta in integrating chromatin hypoacetylation and transcriptional repression. The Journal of Biological Chemistry. 279: 30850-5
Li F, Macfarlan T, Pittman RN, et al. (2002) Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities. The Journal of Biological Chemistry. 277: 45004-12
Seo SB, Macfarlan T, McNamara P, et al. (2002) Regulation of histone acetylation and transcription by nuclear protein pp32, a subunit of the INHAT complex. The Journal of Biological Chemistry. 277: 14005-10
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