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Paul K. Kiptoo, Ph.D.

Affiliations: 
2007 University of Kentucky, Lexington, KY 
Area:
Pharmaceutical Chemistry
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Audra L. Stinchcomb grad student 2007 University of Kentucky
 (Transdermal delivery of naltrexone and its active metabolite, 6-beta-naltrexol, via novel tripartate codrugs linked to bupropion and hydroxybupropion.)

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Publications

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Kopec BM, Kiptoo P, Zhao L, et al. (2019) Non-Invasive Brain Delivery and Efficacy of BDNF to Stimulate Neuroregeneration and Suppression of Disease Relapse in EAE Mice. Molecular Pharmaceutics
Singh RK, van Haandel L, Kiptoo P, et al. (2019) Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model. European Journal of Pharmacology
White DR, Khedri Z, Kiptoo P, et al. (2017) Synthesis of a Bifunctional Peptide Inhibitor-IgG1 Fc Fusion that Suppresses Experimental Autoimmune Encephalomyelitis. Bioconjugate Chemistry
Alaofi A, On N, Kiptoo P, et al. (2016) Comparison of Linear and Cyclic His-Ala-Val Peptides in Modulating the Blood-Brain Barrier Permeability: Impact on Delivery of Molecules to the Brain. Journal of Pharmaceutical Sciences. 105: 797-807
Tabanor K, Lee P, Kiptoo P, et al. (2015) Brain Delivery of Drug and MRI Contrast Agent: Detection and Quantitative Determination of Brain Deposition of CPT-Glu Using LC-MS/MS and Gd-DTPA Using Magnetic Resonance Imaging. Molecular Pharmaceutics
Badawi AH, Kiptoo P, Siahaan TJ. (2015) Immune Tolerance Induction against Experimental Autoimmune Encephalomyelitis (EAE) Using A New PLP-B7AP Conjugate that Simultaneously Targets B7/CD28 Costimulatory Signal and TCR/MHC-II Signal. Journal of Multiple Sclerosis. 2
Laksitorini MD, Kiptoo PK, On NH, et al. (2015) Modulation of intercellular junctions by cyclic-ADT peptides as a method to reversibly increase blood-brain barrier permeability. Journal of Pharmaceutical Sciences. 104: 1065-75
Büyüktimkin B, Kiptoo P, Siahaan TJ. (2014) Bifunctional Peptide Inhibitors Suppress Interleukin-6 Proliferation and Ameliorates Murine Collagen-Induced Arthritis. Journal of Clinical & Cellular Immunology. 5
Laksitorini M, Prasasty VD, Kiptoo PK, et al. (2014) Pathways and progress in improving drug delivery through the intestinal mucosa and blood-brain barriers. Therapeutic Delivery. 5: 1143-63
On NH, Kiptoo P, Siahaan TJ, et al. (2014) Modulation of blood-brain barrier permeability in mice using synthetic E-cadherin peptide. Molecular Pharmaceutics. 11: 974-81
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