Frances H. Arnold

California Institute of Technology, Pasadena, CA 
Protein engineering, directed protein evolution, structure-guided protein recombination, biocatalysis, biofuels
"Frances Arnold"
The Nobel Prize in Chemistry 2018 was divided, one half awarded to Frances H. Arnold "for the directed evolution of enzymes", the other half jointly to George P. Smith and Sir Gregory P. Winter "for the phage display of peptides and antibodies."

Mean distance: 7.74


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Harvey W. Blanch grad student 1985 UC Berkeley
 (Design and scale-up of affinity separations)
Ignacio Tinoco post-doc 1986 UC Berkeley


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Jerzy Olgierd Szablowski research assistant 2007-2007 Caltech (Neurotree)
Jeese Bloom grad student Fred Hutch Cancer Research Center
Huimin Zhao grad student Caltech
Kai Chen grad student 2015- Caltech
Daniel W. Pack grad student 1990-1996 Caltech (BME Tree)
Anne Y. Fu grad student 2002 Caltech
John M. Joern grad student 2003 Caltech
Lianhong Sun grad student 2003 Caltech
Todd Thorsen grad student 2003 Caltech
Christopher A. Voigt grad student 2003 Caltech
Jeffrey B. Endelman grad student 2005 Caltech
Peter Meinhold grad student 2005 Caltech
Andrew K. Udit grad student 2005 Caltech
Cynthia H. Collins grad student 2006 Caltech
D. Allan Drummond grad student 2006 Caltech
Michelle M. Meyer grad student 2006 Caltech
Alexander V. Tobias grad student 2006 Caltech
Sarah K. Brenner grad student 2009 Caltech
Martina N. Carbone grad student 2010 Caltech
Russell S. Komor grad student 2012 Caltech
Philip A. Romero grad student 2012 Caltech
Pedro d. Coelho grad student 2013 Caltech
Indira Wu grad student 2013 Caltech
Christopher C. Farwell grad student 2015 Caltech
Andrew Buller post-doc Caltech
Jennifer Kan post-doc Caltech
Jonathan J. (Joff) Silberg post-doc
Lingchong You post-doc Caltech, Stanford (BME Tree)
Grzegorz Kubik post-doc 2016- Caltech
Zhen Liu post-doc 2020- Caltech
Runze Mao post-doc 2021- Caltech
Zhibin Guan post-doc 1994-1995 Caltech
Manish N Raizada post-doc 2003-2004 Caltech
Rudi Fasan post-doc 2005-2008 Caltech
Jared C. Lewis post-doc 2007-2010 Caltech
Eric M. Brustad post-doc 2008-2012 Caltech
Todd K. Hyster post-doc 2013-2015 Princeton
Hans Renata post-doc 2013-2015 Caltech
Austin J. Rice post-doc 2014-2018 Caltech
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Athavale S, Gao S, Liu Z, et al. (2021) Biocatalytic, Intermolecular C-H Bond Functionalization for the Synthesis of Enantioenriched Amides. Angewandte Chemie (International Ed. in English)
Wittmann BJ, Yue Y, Arnold FH. (2021) Informed training set design enables efficient machine learning-assisted directed protein evolution. Cell Systems
Watkins-Dulaney EJ, Dunham NP, Straathof S, et al. (2021) Asymmetric Alkylation of Ketones Catalyzed by Engineered TrpB. Angewandte Chemie (International Ed. in English)
Sarai NS, Levin BJ, Roberts JM, et al. (2021) Biocatalytic Transformations of Silicon-the Other Group 14 Element. Acs Central Science. 7: 944-953
Wu Z, Johnston KE, Arnold FH, et al. (2021) Protein sequence design with deep generative models. Current Opinion in Chemical Biology. 65: 18-27
Garcia-Borràs M, Kan SBJ, Lewis RD, et al. (2021) Origin and Control of Chemoselectivity in Cytochrome Catalyzed Carbene Transfer into Si-H and N-H bonds. Journal of the American Chemical Society
Wittmann BJ, Johnston KE, Wu Z, et al. (2021) Advances in machine learning for directed evolution. Current Opinion in Structural Biology. 69: 11-18
Miller CE, Ward J, Yoganantham DC, et al. (2021) Evaluation of internet derived patient information for Acute Pancreatitis. The Ulster Medical Journal. 90: 7-9
Zhou H, Lin S, Li X, et al. (2021) Serum miR-222 is independently associated with atrial fibrillation in patients with degenerative valvular heart disease. Bmc Cardiovascular Disorders. 21: 98
Yang Y, Arnold FH. (2021) Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective Carbene and Nitrene Transfer. Accounts of Chemical Research
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