Frances H. Arnold

California Institute of Technology, Pasadena, CA 
Protein engineering, directed protein evolution, structure-guided protein recombination, biocatalysis, biofuels
"Frances Arnold"
The Nobel Prize in Chemistry 2018 was divided, one half awarded to Frances H. Arnold "for the directed evolution of enzymes", the other half jointly to George P. Smith and Sir Gregory P. Winter "for the phage display of peptides and antibodies."

Mean distance: 7.74


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Harvey W. Blanch grad student 1985 UC Berkeley
 (Design and scale-up of affinity separations)
Ignacio Tinoco post-doc 1986 UC Berkeley


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Jerzy Olgierd Szablowski research assistant 2007-2007 Caltech (Neurotree)
Tristan R Brown research assistant 2007-2011 Caltech
Jeese Bloom grad student Fred Hutch Cancer Research Center
Huimin Zhao grad student Caltech
Kai Chen grad student 2015- Caltech
Daniel W. Pack grad student 1990-1996 Caltech (BME Tree)
Anne Y. Fu grad student 2002 Caltech
John M. Joern grad student 2003 Caltech
Lianhong Sun grad student 2003 Caltech
Todd Thorsen grad student 2003 Caltech
Christopher A. Voigt grad student 2003 Caltech
Jeffrey B. Endelman grad student 2005 Caltech
Peter Meinhold grad student 2005 Caltech
Andrew K. Udit grad student 2005 Caltech
Cynthia H. Collins grad student 2006 Caltech
D. Allan Drummond grad student 2006 Caltech
Michelle M. Meyer grad student 2006 Caltech
Alexander V. Tobias grad student 2006 Caltech
Sarah K. Brenner grad student 2009 Caltech
Martina N. Carbone grad student 2010 Caltech
Russell S. Komor grad student 2012 Caltech
Philip A. Romero grad student 2012 Caltech
Pedro d. Coelho grad student 2013 Caltech
Indira Wu grad student 2013 Caltech
Christopher C. Farwell grad student 2015 Caltech
Andrew Buller post-doc Caltech
Jennifer Kan post-doc Caltech
Ulrich Schwaneberg post-doc Caltech
Jonathan J. (Joff) Silberg post-doc
Yang Yang post-doc Caltech
Lingchong You post-doc Caltech, Stanford (BME Tree)
Grzegorz Kubik post-doc 2016- Caltech
Zhen Liu post-doc 2020- Caltech
Runze Mao post-doc 2021- Caltech
Zhibin Guan post-doc 1994-1995 Caltech
Yohei Yokobayashi post-doc 2001-2004 Caltech
Manish N Raizada post-doc 2003-2004 Caltech
Rudi Fasan post-doc 2005-2008 Caltech
Jared C. Lewis post-doc 2007-2010 Caltech
Sang Taek Jung post-doc 2010-2011 Caltech
Eric M. Brustad post-doc 2008-2012 Caltech
Todd K. Hyster post-doc 2013-2015 Princeton
Hans Renata post-doc 2013-2015 Caltech
Austin J. Rice post-doc 2014-2018 Caltech
Anuvab Das post-doc 2020-2024 Caltech
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Yang J, Li FZ, Arnold FH. (2024) Opportunities and Challenges for Machine Learning-Assisted Enzyme Engineering. Acs Central Science. 10: 226-241
Wackelin DJ, Mao R, Sicinski KM, et al. (2024) Enzymatic Assembly of Diverse Lactone Structures: An Intramolecular C-H Functionalization Strategy. Journal of the American Chemical Society
Qin ZY, Gao S, Zou Y, et al. (2023) Biocatalytic Construction of Chiral Pyrrolidines and Indolines via Intramolecular C(sp)-H Amination. Acs Central Science. 9: 2333-2338
Mao R, Wackelin DJ, Jamieson CS, et al. (2023) Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (/)-Trisubstituted Enol Acetates. Journal of the American Chemical Society
Calvó-Tusell C, Liu Z, Chen K, et al. (2023) Reversing the Enantioselectivity of Enzymatic Carbene N-H Insertion Through Mechanism-Guided Protein Engineering. Angewandte Chemie (International Ed. in English). e202303879
Mao R, Wackelin DJ, Jamieson CS, et al. (2023) Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (Z/E)-Trisubstituted Enol Acetates. Research Square
Zhang J, Maggiolo AO, Alfonzo E, et al. (2023) Chemodivergent C(sp)-H and C(sp)-H Cyanomethylation Using Engineered Carbene Transferases. Nature Catalysis. 6: 152-160
Miller DC, Athavale SV, Arnold FH. (2022) Combining chemistry and protein engineering for new-to-nature biocatalysis. Nature Synthesis. 1: 18-23
Liu Z, Qin ZY, Zhu L, et al. (2021) An Enzymatic Platform for Primary Amination of 1-Aryl-2-alkyl Alkynes. Journal of the American Chemical Society
Liu Z, Calvó-Tusell C, Zhou AZ, et al. (2021) Dual-function enzyme catalysis for enantioselective carbon-nitrogen bond formation. Nature Chemistry. 13: 1166-1172
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