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Shu-ou Shan

Affiliations: 
California Institute of Technology, Pasadena, CA 
Area:
Macromolecular machines; protein sorting and localization; molecular recognition and regulation by novel GTPases; protein and nucleic acid structure and function
Website:
http://www.cce.caltech.edu/faculty/shan/index.html
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"Shu-ou Shan"
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SNBCP

Parents

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Daniel Herschlag grad student 2000 Stanford
 (Part I. Energetic analysis of hydrogen bonds in model systems: Implications for enzymatic catalysis. Part II. Probing the role of metal ions in catalysis by the Tetrahymena group I ribozyme.)
Peter Walter post-doc 2005 UCSF

Children

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Xin Zhang grad student Scripps Institute
Peera Jaru-Ampornpan grad student 2011 Caltech
Thang Xuan Nguyen grad student 2013 Caltech
Kuang Shen grad student 2013 Caltech
David Akopian grad student 2014 Caltech
Aileen Renia Ariosa grad student 2014 Caltech
Michael Evan Rome grad student 2014 Caltech
Meera Rao grad student 2016 Caltech
Un Seng Chio grad student 2019 Caltech
Yu-Hsien Hwang Fu grad student 2019 Caltech
Shuai Wang grad student 2013-2019 Caltech (Neurotree)
Ishu Saraogi post-doc Caltech
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Publications

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Yang CI, Hsieh HH, Shan SO. (2019) Timing and specificity of cotranslational nascent protein modification in bacteria. Proceedings of the National Academy of Sciences of the United States of America
Wang S, Jomaa A, Jaskolowski M, et al. (2019) The molecular mechanism of cotranslational membrane protein recognition and targeting by SecA. Nature Structural & Molecular Biology
Hwang Fu YH, Chandrasekar S, Lee JH, et al. (2019) A molecular recognition feature mediates ribosome-induced SRP-receptor assembly during protein targeting. The Journal of Cell Biology
Chio US, Chung S, Weiss S, et al. (2019) A Chaperone Lid Ensures Efficient and Privileged Client Transfer during Tail-Anchored Protein Targeting. Cell Reports. 26: 37-44.e7
Cho H, Chio US, Shan SO. (2018) In vitro Assays for Targeting and Insertion of Tail-Anchored Proteins Into the ER Membrane. Current Protocols in Cell Biology. e63
Cho H, Shan SO. (2018) Substrate relay in an Hsp70-cochaperone cascade safeguards tail-anchored membrane protein targeting. The Embo Journal
Lee JH, Chandrasekar S, Chung S, et al. (2018) Sequential activation of human signal recognition particle by the ribosome and signal sequence drives efficient protein targeting. Proceedings of the National Academy of Sciences of the United States of America
McAvoy C, Siegel A, Piszkiewicz S, et al. (2018) Two Distinct Sites of client protein interaction with the chaperone cpSRP43. The Journal of Biological Chemistry
Wang P, Liang FC, Wittmann D, et al. (2018) Chloroplast SRP43 acts as a chaperone for glutamyl-tRNA reductase, the rate-limiting enzyme in tetrapyrrole biosynthesis. Proceedings of the National Academy of Sciences of the United States of America
Kobayashi K, Jomaa A, Lee JH, et al. (2018) Structure of a prehandover mammalian ribosomal SRP•SRP receptor targeting complex. Science (New York, N.Y.)
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