Alex J. Vecchio, Ph.D.
Affiliations: | 2011 | Structural Biology | State University of New York, Buffalo, Buffalo, NY, United States |
Area:
General Biophysics, Biochemistry, Molecular BiologyGoogle:
"Alex Vecchio"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Michael G. Malkowski | grad student | 2011 | SUNY Buffalo | |
| (Biochemical and structural characterization of substrate binding to cyclooxygenase-2 insights into catalysis and inhibition.) | ||||
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Publications
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| Ogbu CP, Kapoor S, Vecchio AJ. (2023) Structural Basis of Enterotoxin Activation and Oligomerization by Trypsin. Toxins. 15 |
| Erramilli SK, Dominik PK, Ogbu CP, et al. (2023) Cryo-EM structures of a synthetic antibody against 22 kDa claudin-4 reveal its complex with enterotoxin. Biorxiv : the Preprint Server For Biology |
| Orlando BJ, Dominik PK, Roy S, et al. (2022) Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes. The Journal of Biological Chemistry. 102357 |
| Vecchio AJ, Rathnayake SS, Stroud RM. (2021) Structural basis for enterotoxin targeting of claudins at tight junctions in mammalian gut. Proceedings of the National Academy of Sciences of the United States of America. 118 |
| Vecchio AJ, Stroud RM. (2019) Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown. Proceedings of the National Academy of Sciences of the United States of America |
| Lucido MJ, Orlando BJ, Vecchio AJ, et al. (2016) Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. Biochemistry. 55: 1226-38 |
| Vecchio AJ, Orlando BJ, Nandagiri R, et al. (2012) Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove. The Journal of Biological Chemistry. 287: 24619-30 |
| Vecchio AJ, Malkowski MG. (2011) The structure of NS-398 bound to cyclooxygenase-2. Journal of Structural Biology. 176: 254-8 |
| Vecchio AJ, Malkowski MG. (2011) The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. The Journal of Biological Chemistry. 286: 20736-45 |
| Dong L, Vecchio AJ, Sharma NP, et al. (2011) Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer. The Journal of Biological Chemistry. 286: 19035-46 |