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Robert H. Tukey

Affiliations:

University of California, San Diego, La Jolla, CA

Area:

The role of environmental and chemical toxicants on gene expression

Website:

http://www-chem.ucsd.edu/faculty/profiles/tukey_robert_h.html

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Parents

Thomas R. Tephly	grad student	1980	University of Iowa
(Separation, purification and characterization of estrone and p-nitrophenol UDP-glucuronyltransferases from rabbit liver microsomes)

Children

Daniel E. Machemer	grad student	2005	UCSD
Jessica A. Bonzo	grad student	2007	UCSD
Theresa N. Operana	grad student	2008	UCSD
Erin J. Sinnokrak	grad student	2010	UCSD
Camille M. Konopnicki	grad student	2012	UCSD

Collaborators

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Publications

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Yang X, Weber AA, Mennillo E, et al. (2023) Oral arsenic administration to humanized UDP-glucuronosyltransferase (UGT) 1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR. The Journal of Biological Chemistry. 102955
Mennillo E, Yang X, Weber AA, et al. (2022) Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 50: 33-42
Yueh MF, He F, Chen C, et al. (2020) Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proceedings of the National Academy of Sciences of the United States of America
Weber AW, Mennillo E, Yang X, et al. (2020) . Drug Metabolism and Disposition: the Biological Fate of Chemicals
Hansmann E, Mennillo E, Yoda E, et al. (2020) Differential role of LXRα and LXRβ in the regulation of UDP-glucuronosyltransferase 1A1 in humanized UGT1 mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals
Weber AA, Mennillo E, Ding J, et al. (2020) Triclosan (TCS) Exposure in Neonatal Mice Leads to ER Stress, Inflammation and Lipid Accumulation in Liver The Faseb Journal. 34: 1-1
Yang X, Mennillo E, Tukey R, et al. (2020) Comparisons between Animal Models and Intestinal Crypt Cultures when Investigating the Impact of Fatty Acids on Gene Expression in Intestinal Epithelial Cells The Faseb Journal. 34: 1-1
Mennillo E, Yang X, Weber A, et al. (2020) Tissue‐specific Humanized Models Expressing Human UGT1A1 The Faseb Journal. 34: 1-1
Paszek M, Tukey RH. (2019) NRF2-independent regulation of CAR by the pro-oxidants cadmium and isothiocyanate in hUGT1 mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals
Chen S, Tukey RH. (2018) Humanized UGT1 mice, regulation of UGT1A1,and the role of the intestinal tract in neonatal hyperbilirubinemia and breast milk induced jaundice. Drug Metabolism and Disposition: the Biological Fate of Chemicals

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