Alem Kahsai
Affiliations: | University of Connecticut, Storrs, CT, United States |
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Parents
Sign in to add mentor| Gabriel Fenteany | grad student | University of Connecticut | |
| Robert J. Lefkowitz | research scientist | Duke |
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| Liu X, Masoudi A, Kahsai AW, et al. (2019) Mechanism of βAR regulation by an intracellular positive allosteric modulator. Science (New York, N.Y.). 364: 1283-1287 |
| Kahsai AW, Pani B, Lefkowitz RJ. (2018) GPCR signaling: conformational activation of arrestins. Cell Research |
| Ahn S, Pani B, Kahsai AW, et al. (2018) Small Molecule Positive Allosteric Modulators of the β-Adrenoceptor Isolated from DNA Encoded Libraries. Molecular Pharmacology |
| Meng K, Shim P, Wang Q, et al. (2018) Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β-adrenergic receptor. Bioorganic & Medicinal Chemistry |
| Liu X, Ahn S, Kahsai AW, et al. (2017) Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. Nature |
| Cahill TJ, Thomsen AR, Tarrasch JT, et al. (2017) Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. Proceedings of the National Academy of Sciences of the United States of America |
| Ahn S, Kahsai AW, Pani B, et al. (2017) Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library. Proceedings of the National Academy of Sciences of the United States of America |
| Thomsen AR, Plouffe B, Cahill TJ, et al. (2016) GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. Cell |
| Staus DP, Strachan RT, Manglik A, et al. (2016) Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature |
| Kahsai AW, Wisler JW, Lee J, et al. (2016) Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor. Nature Chemical Biology |