Alem Kahsai

Affiliations: 
University of Connecticut, Storrs, CT, United States 
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"Alem Kahsai"
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Liu X, Masoudi A, Kahsai AW, et al. (2019) Mechanism of βAR regulation by an intracellular positive allosteric modulator. Science (New York, N.Y.). 364: 1283-1287
Kahsai AW, Pani B, Lefkowitz RJ. (2018) GPCR signaling: conformational activation of arrestins. Cell Research
Ahn S, Pani B, Kahsai AW, et al. (2018) Small Molecule Positive Allosteric Modulators of the β-Adrenoceptor Isolated from DNA Encoded Libraries. Molecular Pharmacology
Meng K, Shim P, Wang Q, et al. (2018) Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β-adrenergic receptor. Bioorganic & Medicinal Chemistry
Liu X, Ahn S, Kahsai AW, et al. (2017) Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. Nature
Cahill TJ, Thomsen AR, Tarrasch JT, et al. (2017) Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. Proceedings of the National Academy of Sciences of the United States of America
Ahn S, Kahsai AW, Pani B, et al. (2017) Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library. Proceedings of the National Academy of Sciences of the United States of America
Thomsen AR, Plouffe B, Cahill TJ, et al. (2016) GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. Cell
Staus DP, Strachan RT, Manglik A, et al. (2016) Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature
Kahsai AW, Wisler JW, Lee J, et al. (2016) Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor. Nature Chemical Biology
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