Lorena S. Beese, Ph.D.
Affiliations: | Biochemistry | Duke University, Durham, NC |
Area:
Structural BiologyWebsite:
http://www.nasonline.org/member-directory/members/20020245.htmlGoogle:
"Lorena S. Beese"Bio:
http://www.biochem.duke.edu/modules/biochem_beese_lab/index.php?id=1
http://www.phy.duke.edu/~hsg/174/talk-files/beese_biophys.pdf
Mean distance: 8.22 | S | N | B | C | P |
Parents
Sign in to add mentor| Carolyn Cohen | grad student | 1984 | Brandeis | |
| ( Microtubule Structure: An Analysis by X-ray Diffraction) | ||||
| Thomas A. Steitz | post-doc | 1986-1992 | Yale | |
Children
Sign in to add trainee| Stephen B. Long | grad student | 2001 | Duke |
| Gerald W. Hsu | grad student | 2005 | Duke |
| Kimberly L. Terry | grad student | 2005 | Duke |
| Timothy J. Pohlhaus | grad student | 2006 | Duke |
| Weina Wang | grad student | 2012 | Duke |
BETA: Related publications
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Publications
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| Wang Y, Shi Y, Hellinga HW, et al. (2023) Thermally controlled intein splicing of engineered DNA polymerases provides a robust and generalizable solution for accurate and sensitive molecular diagnostics. Nucleic Acids Research |
| Beese LS, Shi Y, Wang Y. (2019) Using time-resolved crystallography and cryo-EM to investigate human DNA repair nucleases Acta Crystallographica Section a Foundations and Advances. 75: a153-a153 |
| Kato N, Kawasoe Y, Williams H, et al. (2017) Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway. Cell Reports. 21: 1375-1385 |
| Shi Y, Hellinga HW, Beese LS. (2017) Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I. Proceedings of the National Academy of Sciences of the United States of America |
| Miller BR, Beese LS, Parish CA, et al. (2015) The Closing Mechanism of DNA Polymerase I at Atomic Resolution. Structure (London, England : 1993). 23: 1609-20 |
| Wang YC, Dozier JK, Beese LS, et al. (2014) Rapid analysis of protein farnesyltransferase substrate specificity using peptide libraries and isoprenoid diphosphate analogues. Acs Chemical Biology. 9: 1726-35 |
| Mabanglo MF, Hast MA, Lubock NB, et al. (2014) Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Science : a Publication of the Protein Society. 23: 289-301 |
| Grimley JS, Li L, Wang W, et al. (2013) Visualization of synaptic inhibition with an optogenetic sensor developed by cell-free protein engineering automation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 16297-309 |
| Khatwani SL, Kang JS, Mullen DG, et al. (2012) Covalent protein-oligonucleotide conjugates by copper-free click reaction. Bioorganic & Medicinal Chemistry. 20: 4532-9 |
| Wang W, Wu EY, Hellinga HW, et al. (2012) Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides. The Journal of Biological Chemistry. 287: 28215-26 |