Lorena S. Beese, Ph.D.

Biochemistry Duke University, Durham, NC 
Structural Biology
"Lorena S. Beese"


Mean distance: 8.22


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Carolyn Cohen grad student 1984 Brandeis
 ( Microtubule Structure: An Analysis by X-ray Diffraction)
Thomas A. Steitz post-doc 1986-1992 Yale


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Stephen B. Long grad student 2001 Duke
Gerald W. Hsu grad student 2005 Duke
Kimberly L. Terry grad student 2005 Duke
Timothy J. Pohlhaus grad student 2006 Duke
Weina Wang grad student 2012 Duke
BETA: Related publications


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Wang Y, Shi Y, Hellinga HW, et al. (2023) Thermally controlled intein splicing of engineered DNA polymerases provides a robust and generalizable solution for accurate and sensitive molecular diagnostics. Nucleic Acids Research
Beese LS, Shi Y, Wang Y. (2019) Using time-resolved crystallography and cryo-EM to investigate human DNA repair nucleases Acta Crystallographica Section a Foundations and Advances. 75: a153-a153
Kato N, Kawasoe Y, Williams H, et al. (2017) Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway. Cell Reports. 21: 1375-1385
Shi Y, Hellinga HW, Beese LS. (2017) Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I. Proceedings of the National Academy of Sciences of the United States of America
Miller BR, Beese LS, Parish CA, et al. (2015) The Closing Mechanism of DNA Polymerase I at Atomic Resolution. Structure (London, England : 1993). 23: 1609-20
Wang YC, Dozier JK, Beese LS, et al. (2014) Rapid analysis of protein farnesyltransferase substrate specificity using peptide libraries and isoprenoid diphosphate analogues. Acs Chemical Biology. 9: 1726-35
Mabanglo MF, Hast MA, Lubock NB, et al. (2014) Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Science : a Publication of the Protein Society. 23: 289-301
Grimley JS, Li L, Wang W, et al. (2013) Visualization of synaptic inhibition with an optogenetic sensor developed by cell-free protein engineering automation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 16297-309
Khatwani SL, Kang JS, Mullen DG, et al. (2012) Covalent protein-oligonucleotide conjugates by copper-free click reaction. Bioorganic & Medicinal Chemistry. 20: 4532-9
Wang W, Wu EY, Hellinga HW, et al. (2012) Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides. The Journal of Biological Chemistry. 287: 28215-26
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