Celia A. Schiffer
Affiliations: | 1997- | Biochemistry & Molecular Biotechnology | University of Massachusetts Chan Medical School |
Area:
Structural basis for molecular recognition in HIV ProteaseWebsite:
www.umassmed.edu/schifferlabGoogle:
"celia schiffer"Mean distance: 8.63
Parents
Sign in to add mentor| Robert M. Stroud | grad student | 1986-1992 | UCSF | |
| (Protein structure determination) | ||||
| Wilfred F. van Gunsteren | post-doc | 1992-1994 | ETH Zürich | |
| Anthony A. Kossiakoff | post-doc | 1994-1997 | Genentech, Inc. | |
Children
Sign in to add trainee| Kelly Marie Thayer | grad student | 2007-2009 | University of Massachusetts Medical School, USA |
BETA: Related publications
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Publications
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| Azzolino VN, Shaqra AM, Ali A, et al. (2025) Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease. Viruses. 17 |
| Azzolino VN, Shaqra AM, Ali A, et al. (2024) Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance. Viruses. 16 |
| Flynn JM, Huang QYJ, Zvornicanin SN, et al. (2023) Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease. Acs Infectious Diseases |
| Lockbaum GJ, Rusere LN, Henes M, et al. (2023) HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues. European Journal of Medicinal Chemistry. 257: 115501 |
| Spielvogel E, Lee SK, Zhou S, et al. (2023) Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance. Elife. 12 |
| Shaqra AM, Zvornicanin SN, Huang QYJ, et al. (2022) Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nature Communications. 13: 3556 |
| Zephyr J, Nageswara Rao D, Vo SV, et al. (2022) Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance. Journal of Molecular Biology. 167503 |
| Zephyr J, Kurt Yilmaz N, Schiffer CA. (2021) Viral proteases: Structure, mechanism and inhibition. The Enzymes. 50: 301-333 |
| Leidner F, Kurt Yilmaz N, Schiffer CA. (2021) Deciphering Complex Mechanisms of Resistance and Loss of Potency through Coupled Molecular Dynamics and Machine Learning. Journal of Chemical Theory and Computation |
| Rusere LN, Lockbaum GJ, Henes M, et al. (2020) Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-Tetrahydrofuran in a Pseudo-Symmetric Dipeptide Isostere. Journal of Medicinal Chemistry |