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Celia A. Schiffer

Biochemistry & Molecular Pharmacology University of Massachusetts Medical School, Worcester, MA, United States 
Structural basis for molecular recognition in HIV Protease
"Celia Schiffer"
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Robert M. Stroud grad student 1986-1992 UCSF
 (Protein structure determination)
Wilfred F. van Gunsteren post-doc 1992-1994 ETH Zürich
Anthony A. Kossiakoff post-doc 1994-1997 Genentech, Inc.
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Rusere LN, Lockbaum GJ, Henes M, et al. (2020) Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-Tetrahydrofuran in a Pseudo-Symmetric Dipeptide Isostere. Journal of Medicinal Chemistry
Matthew AN, Zephyr J, Nageswara Rao D, et al. (2020) Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors. Mbio. 11
Schiffer C. (2020) Constraining evolution → avoiding drug resistance: lessons from viruses The Faseb Journal. 34: 1-1
Royer WE, Nichols JC, Schiffer CA. (2020) Illuminating the Structural Determinants for Tetrameric Assembly of Oncogenic CtBP to Guide Inhibitor Design Biophysical Journal. 118: 46a
Whitfield TW, Ragland DA, Zeldovich KB, et al. (2019) Characterizing protein-ligand binding using atomistic simulation and machine learning: Application to drug resistance in HIV-1 protease. Journal of Chemical Theory and Computation
Timm J, Kosovrasti K, Henes M, et al. (2019) Molecular and structural mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir. Acs Chemical Biology
Solomon WC, Myint W, Hou S, et al. (2019) Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA. Nucleic Acids Research. 47: 7676-7689
Rusere LN, Lockbaum GJ, Lee SK, et al. (2019) HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands to Optimize Hydrogen Bonding in the Substrate Envelope. Journal of Medicinal Chemistry
Henes M, Kosovrasti K, Lockbaum GJ, et al. (2019) Molecular determinants of epistasis in HIV-1 protease: Elucidating the interdependence of L89V and L90M mutations in resistance. Biochemistry
Leidner F, Kurt Yilmaz N, Schiffer CA. (2019) Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints. Journal of Chemical Information and Modeling
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