Brent R. Stockwell

Chemistry Columbia University, New York, NY 
to identify compounds and proteins that act as critical regulators of cancer and neurodegeneration
"Brent Stockwell"

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Stuart L. Schreiber grad student 1999 Harvard
 (Forward and reverse chemical genetic studies of transforming growth factor beta signaling)


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Kathryn M. Lemberg grad student 2011 Columbia
Adam J. Wolpaw grad student 2011 Columbia
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Zhang Y, Tan H, Daniels JD, et al. (2019) Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model. Cell Chemical Biology
Gaschler MM, Andia AA, Liu H, et al. (2018) FINOinitiates ferroptosis through GPX4 inactivation and iron oxidation. Nature Chemical Biology
Liu H, Schreiber SL, Stockwell BR. (2018) Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy. Biochemistry
Viswanathan VS, Ryan MJ, Dhruv HD, et al. (2017) Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature
Welsch ME, Kaplan A, Chambers JM, et al. (2017) Multivalent Small-Molecule Pan-RAS Inhibitors. Cell. 168: 878-889.e29
Yang WS, Kim KJ, Gaschler MM, et al. (2016) Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proceedings of the National Academy of Sciences of the United States of America
Gerhard DS, Clemons PA, Shamji AF, et al. (2016) Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance. Molecular Cancer Research : McR
Shimada K, Skouta R, Kaplan A, et al. (2016) Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nature Chemical Biology
Shimada K, Hayano M, Pagano NC, et al. (2016) Cell-Line Selectivity Improves the Predictive Power of Pharmacogenomic Analyses and Helps Identify NADPH as Biomarker for Ferroptosis Sensitivity. Cell Chemical Biology
Yang WS, Stockwell BR. (2015) Ferroptosis: Death by Lipid Peroxidation. Trends in Cell Biology
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