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Emmanuel Skordalakes

Chemistry University of Pennsylvania, Philadelphia, PA, United States 
Gene Expression and Regulation
"Emmanuel Skordalakes"
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Zhu H, Ren S, Bitler BG, et al. (2015) SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase. Cell Reports
Bryan C, Rice C, Hoffman H, et al. (2015) Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532. Structure (London, England : 1993). 23: 1934-42
Greetham M, Skordalakes E, Lydall D, et al. (2015) The Telomere Binding Protein Cdc13 and the Single-Stranded DNA Binding Protein RPA Protect Telomeric DNA from Resection by Exonucleases. Journal of Molecular Biology. 427: 3023-30
Iwasaki O, Tanizawa H, Kim KD, et al. (2015) Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes. Molecular Cell. 59: 755-67
Panneer Selvam S, De Palma RM, Oaks JJ, et al. (2015) Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Science Signaling. 8: ra58
Peng H, Talebzadeh-Farrooji M, Osborne MJ, et al. (2014) LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase. Cancer Research. 74: 1390-403
Bryan C, Rice C, Harkisheimer M, et al. (2014) Structure of the Human Telomeric Stn1-Ten1 Complex Acta Crystallographica Section A. 70
Harkisheimer M, Mason M, Shuvaeva E, et al. (2013) A motif in the vertebrate telomerase N-terminal linker of TERT contributes to RNA binding and telomerase activity and processivity. Structure (London, England : 1993). 21: 1870-8
Bryan C, Rice C, Harkisheimer M, et al. (2013) Structure of the human telomeric Stn1-Ten1 capping complex. Plos One. 8: e66756
Newhart A, Rafalska-Metcalf IU, Yang T, et al. (2013) Single cell analysis of RNA-mediated histone H3.3 recruitment to a cytomegalovirus promoter-regulated transcription site. The Journal of Biological Chemistry. 288: 19882-99
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