Michael J. Eck, MD, Ph.D.

Biological Chemistry and Molecular Pharmacology Harvard Medical School, Boston, MA, United States 
Structural Biology
"Michael Eck"


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Stephen R. Sprang grad student 1987-1991 University of Texas Southwestern Medical School
 (The three-dimensional structure of tumor necrosis factor (TNF-[alpha]) at 2.6 Å resolution)
Stephen C. Harrison post-doc 1991-1996 Harvard Medical School
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De Clercq DJH, Heppner DE, To C, et al. (2019) Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors. Acs Medicinal Chemistry Letters. 10: 1549-1553
Park E, Rawson S, Li K, et al. (2019) Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature
To C, Jang J, Chen T, et al. (2019) Single and dual targeting of mutant EGFR with an allosteric inhibitor. Cancer Discovery
McNally R, Li Q, Li K, et al. (2019) Discovery and structural characterization of ATP-site ligands for the wild-type and V617F-mutant JAK2 pseudokinase domain. Acs Chemical Biology
Jang J, Son J, Park E, et al. (2018) Discovery of a Highly Potent and Broadly Effective EGFR and HER2 Exon 20 Insertion Mutant Inhibitor. Angewandte Chemie (International Ed. in English)
Zhang J, Gao X, Schmit F, et al. (2017) CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells. Cell Reports. 20: 549-557
Ficarro SB, Browne CM, Card JD, et al. (2016) Leveraging Gas-Phase Fragmentation Pathways for Improved Identification and Selective Detection of Targets Modified by Covalent Probes. Analytical Chemistry. 88: 12248-12254
Jia Y, Yun CH, Park E, et al. (2016) Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature. 534: 129-32
McNally R, Toms AV, Eck MJ. (2016) Crystal Structure of the FERM-SH2 Module of Human Jak2. Plos One. 11: e0156218
Meyer PA, Socias S, Key J, et al. (2016) Data publication with the structural biology data grid supports live analysis. Nature Communications. 7: 10882
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