Michael J. Eck, MD, Ph.D.
Affiliations: | Biological Chemistry and Molecular Pharmacology | Harvard Medical School, Boston, MA, United States |
Area:
Structural BiologyWebsite:
http://www.fas.harvard.edu/~biophys/Michael_J_Eck.htmGoogle:
"Michael Eck"Bio:
http://red.dfci.harvard.edu/
http://physicians.dana-farber.org/directory/profile.asp?dbase=main&setsize=10&display=Y&nxtfmt=pc&pgt=Eder%2C+Joseph+P.%2C+MD&gs=pc&grouptype_typeid=1&pict_id=0000117
Mean distance: 8.36 | S | N | B | C | P |
Parents
Sign in to add mentor| Stephen R. Sprang | grad student | 1987-1991 | University of Texas Southwestern Medical School | |
| (The three-dimensional structure of tumor necrosis factor (TNF-[alpha]) at 2.6 Å resolution) | ||||
| Stephen C. Harrison | post-doc | 1991-1996 | Harvard Medical School | |
Children
Sign in to add trainee| Titus Boggon | post-doc | ||
| kunhua Li | post-doc | ||
| Randall McNally | post-doc | Harvard Medical School | |
| Hyun Kyu Song | post-doc | 2001-2003 | Harvard Medical School |
| Humayun Sharif | post-doc | 2014-2015 | Harvard Medical School/Dana-Farber Cancer Institute |
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Publications
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| Zhao H, Beyett TS, Jiang J, et al. (2024) Biochemical analysis of EGFR exon20 insertion variants insASV and insSVD and their inhibitor sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 121: e2417144121 |
| Beyett TS, Rana JK, Schaeffner IK, et al. (2024) Structural analysis of the macrocyclic inhibitor BI-4020 binding to EGFR kinase. Chemmedchem. e202300343 |
| Li Z, Lu W, Beyett TS, et al. (2024) ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases. Journal of Medicinal Chemistry |
| Kim JJ, Schaeffner IK, Heppner DE, et al. (2023) A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology. Molecular Pharmacology |
| Park E, Rawson S, Schmoker A, et al. (2023) Publisher Correction: Cryo-EM structure of a RAS/RAF recruitment complex. Nature Communications. 14: 5517 |
| Park E, Rawson S, Schmoker A, et al. (2023) Cryo-EM structure of a RAS/RAF recruitment complex. Nature Communications. 14: 4580 |
| Damghani T, Wittlinger F, Beyett TS, et al. (2023) Structural elements that enable specificity for mutant EGFR kinase domains with next-generation small-molecule inhibitors. Methods in Enzymology. 685: 171-198 |
| Tkacik E, Li K, Gonzalez-Del Pino G, et al. (2023) Structure and RAF-family kinase isoform selectivity of Type II RAF inhibitors tovorafenib and naporafenib. The Journal of Biological Chemistry. 104634 |
| Heppner DE, Wittlinger F, Beyett TS, et al. (2022) Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448). Acs Medicinal Chemistry Letters. 13: 1856-1863 |
| Bae H, Viennet T, Park E, et al. (2022) PH domain-mediated autoinhibition and oncogenic activation of Akt. Elife. 11 |