Stephen R. Sprang, Ph.D.

Affiliations: 
Biological Science University of Montana, Missoula, MT 
Area:
Structural Biology and Biochemistry: Biological Signal Transduction
Website:
http://www.cas.umt.edu/casweb/faculty/FacultyDetails.cfm?id=941
Google:
"Stephen Sprang"
Bio:

http://www.hhmi.com/research/investigators/sprang_bio.html

Mean distance: 8.11
 
SNBCP

Parents

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Muttaiya (Sunda) Sundaralingam grad student 1977 UW Madison
 (Structural and conformational studies of purine nucleoside analogs)
Robert J. Fletterick post-doc 1983 UCSF
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Publications

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McClelland LJ, Zhang K, Mou TC, et al. (2020) Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1. Nature Communications. 11: 1077
McClelland LJ, Zhang K, Mou T, et al. (2020) Ric8A-Gα, a Complex Structure of a Guanine Nucleotide Exchange Factor Biophysical Journal. 118: 335a
Zeng B, Mou TC, Doukov TI, et al. (2019) Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A. Structure (London, England : 1993)
Sprang S, McClelland L, Johnston J, et al. (2019) The structure of the complex of the cytoplasmic guanine nucleotide exchange factor Ric-8A bound to Gαi1 Acta Crystallographica Section a Foundations and Advances. 75: a175-a175
Maziarz M, Leyme A, Marivin A, et al. (2018) Atypical activation of Gαq by the oncogenic mutation Q209P. The Journal of Biological Chemistry
Stump S, Mou TC, Sprang SR, et al. (2018) Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene. Plos One. 13: e0205584
Sprang S, Zeng B, McClelland L, et al. (2017) Structures of Ric-8A, a G protein chaperone and activator Acta Crystallographica Section a Foundations and Advances. 73: a367-a367
Black LA, Ross J, Sprang SR. (2017) Nucleotide and Nucleotide Exchange Factor Bound Nano to Millisecond Structural-Dynamics of G Alpha Biophysical Journal. 112: 281a
Kant R, Zeng B, Thomas CJ, et al. (2016) Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα. Elife. 5
McClelland LJ, Steele HB, Whitby FG, et al. (2016) Cytochrome c Can Form a Well-Defined Binding Pocket for Hydrocarbons. Journal of the American Chemical Society
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