Robert J. Fletterick
Affiliations: | Biochemistry | University of California, San Francisco, San Francisco, CA |
Area:
X-ray crystal structures of nuclear receptors, kinesin molecular motors, clathrin, and many enzymesWebsite:
http://www.msg.ucsf.edu/flett/index.htmlGoogle:
"Robert Fletterick"Bio:
http://www.nasonline.org/member-directory/members/20022349.html
Mean distance: 7.22 | S | N | B | C | P |
Parents
Sign in to add mentorRobert E. Hughes | grad student | 1970 | Cornell | |
(The crystal and molecular structures of poly(4-methyl pentene) and L-alanyl-L-alanine) | ||||
Thomas A. Steitz | post-doc | Yale |
Children
Sign in to add traineeF. Jon Kull | grad student | 1996 | UCSF |
Manish J. Butte | grad student | 2001 | UCSF |
Bertrand R. Huber | grad student | 2001 | UCSF |
Charles V. Sindelar | grad student | 2002 | UCSF |
Eugene Hur | grad student | 2006 | UCSF |
Krista M. Shipley | grad student | 2006 | UCSF |
Jeremy D. Wilbur | grad student | 2008 | UCSF |
Eric J. Slivka | grad student | 2009 | UCSF |
Leslie A. Cruz | grad student | 2011 | UCSF |
Kristopher M. Kuchenbecker | grad student | 2013 | UCSF |
Stephen R. Sprang | post-doc | 1983 | UCSF |
Linda S Brinen | post-doc | 1994-1998 | UCSF |
Raymond D. Blind | post-doc | 2012-2015 | UCSF (Crystallography Tree) |
R. Kip Guy | research scientist | 1998-2014 | UCSF |
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Publications
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Bruning JM, Wang Y, Oltrabella F, et al. (2019) Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell Chemical Biology |
Bayrer JR, Wang H, Nattiv R, et al. (2018) LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nature Communications. 9: 4055 |
Cortez FJ, Nguyen P, Truillet C, et al. (2017) Development of 5N-Bicalutamide, A High-affinity Reversible Covalent Antiandrogen. Acs Chemical Biology |
de Jesus Cortez F, Suzawa M, Irvy S, et al. (2016) Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2). Plos One. 11: e0159316 |
Proudfoot A, Axelrod HL, Geralt M, et al. (2016) Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome. Journal of Molecular Biology. 428: 1130-1141 |
Suzawa M, Miranda DA, Ramos KA, et al. (2015) A gene-expression screen identifies a non-toxic sumoylation inhibitor that Mimics SUMO-less human LRH-1 in liver. Elife. 4 |
Sablin EP, Blind RD, Uthayaruban R, et al. (2015) Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket. Journal of Structural Biology |
Storer Samaniego C, Suh JH, Chattopadhyay A, et al. (2015) The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling. Plos One. 10: e0134015 |
Hayashi Y, Caboni L, Das D, et al. (2015) Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 4666-71 |
Torres IO, Kuchenbecker KM, Nnadi CI, et al. (2015) Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism. Nature Communications. 6: 6204 |