Robert J. Fletterick

Affiliations: 
Biochemistry University of California, San Francisco, San Francisco, CA 
Area:
X-ray crystal structures of nuclear receptors, kinesin molecular motors, clathrin, and many enzymes
Website:
http://www.msg.ucsf.edu/flett/index.html
Google:
"Robert Fletterick"
Bio:

http://www.nasonline.org/member-directory/members/20022349.html

Mean distance: 7.22
 
SNBCP

Parents

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Robert E. Hughes grad student 1970 Cornell
 (The crystal and molecular structures of poly(4-methyl pentene) and L-alanyl-L-alanine)
Thomas A. Steitz post-doc Yale

Children

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F. Jon Kull grad student 1996 UCSF
Manish J. Butte grad student 2001 UCSF
Bertrand R. Huber grad student 2001 UCSF
Charles V. Sindelar grad student 2002 UCSF
Eugene Hur grad student 2006 UCSF
Krista M. Shipley grad student 2006 UCSF
Jeremy D. Wilbur grad student 2008 UCSF
Eric J. Slivka grad student 2009 UCSF
Leslie A. Cruz grad student 2011 UCSF
Kristopher M. Kuchenbecker grad student 2013 UCSF
Stephen R. Sprang post-doc 1983 UCSF
Linda S Brinen post-doc 1994-1998 UCSF
Raymond D Blind post-doc 2012-2015 UCSF (Crystallography Tree)
R. Kip Guy research scientist 1998-2014 UCSF

Collaborators

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R. Kip Guy collaborator 1998-2005 UCSF
BETA: Related publications

Publications

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Bruning JM, Wang Y, Oltrabella F, et al. (2019) Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell Chemical Biology
Bayrer JR, Wang H, Nattiv R, et al. (2018) LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nature Communications. 9: 4055
Cortez FJ, Nguyen P, Truillet C, et al. (2017) Development of 5N-Bicalutamide, A High-affinity Reversible Covalent Antiandrogen. Acs Chemical Biology
de Jesus Cortez F, Suzawa M, Irvy S, et al. (2016) Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2). Plos One. 11: e0159316
Proudfoot A, Axelrod HL, Geralt M, et al. (2016) Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome. Journal of Molecular Biology. 428: 1130-1141
Suzawa M, Miranda DA, Ramos KA, et al. (2015) A gene-expression screen identifies a non-toxic sumoylation inhibitor that Mimics SUMO-less human LRH-1 in liver. Elife. 4
Sablin EP, Blind RD, Uthayaruban R, et al. (2015) Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket. Journal of Structural Biology
Storer Samaniego C, Suh JH, Chattopadhyay A, et al. (2015) The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling. Plos One. 10: e0134015
Hayashi Y, Caboni L, Das D, et al. (2015) Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 4666-71
Torres IO, Kuchenbecker KM, Nnadi CI, et al. (2015) Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism. Nature Communications. 6: 6204
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