Weijun Shen

Affiliations: 
California Institute for Biomedical Research 
Area:
drug discovery, peptide engineering, cell biology, high throughput screening,
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"Weijun Shen"
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Parents

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David B. Berkowitz grad student 2001-2007 University of Nebraska - Lincoln
 (I. Development of a new assay and inhibitors for human cystathionine beta-synthase. II. Asymmetric catalyst development guided by in situ enzymatic screening (ISES).)
Peter G. Schultz post-doc 2007-2009 Scripps Research Institute
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Publications

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Yang Y, Lee C, Reddy RR, et al. (2022) Design of Potent and Proteolytically Stable Biaryl-Stapled GLP-1R/GIPR Peptide Dual Agonists. Acs Chemical Biology
Marrocco V, Tran T, Zhu S, et al. (2021) A small molecule UPR modulator for diabetes identified by high throughput screening. Acta Pharmaceutica Sinica. B. 11: 3983-3993
Sang P, Zeng H, Lee C, et al. (2021) α/Sulfono-γ-AApeptide Hybrid Analogues of Glucagon with Enhanced Stability and Prolonged In Vivo Activity. Journal of Medicinal Chemistry
Shalhout SZ, Yang PY, Grzelak EM, et al. (2021) YAP-dependent proliferation by a small molecule targeting annexin A2. Nature Chemical Biology
Lear S, Pflimlin E, Zhou Z, et al. (2020) Engineering of a Potent, Long-Acting NPY2R Agonist for Combination with a GLP-1R Agonist as a Multi-Hormonal Treatment for Obesity. Journal of Medicinal Chemistry
Liu YA, Jin Q, Ding Q, et al. (2020) A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877. Chemmedchem
Lear S, Seo H, Lee C, et al. (2020) Recombinant Expression and Stapling of a Novel Long-Acting GLP-1R Peptide Agonist. Molecules (Basel, Switzerland). 25
Sang P, Zhou Z, Shi Y, et al. (2020) The activity of sulfono-γ-AApeptide helical foldamers that mimic GLP-1. Science Advances. 6: eaaz4988
Yang PY, Zou H, Amso Z, et al. (2020) New Generation Oxyntomodulin Peptides with Improved Pharmacokinetic Profiles Exhibit Weight Reducing and Anti-Steatotic Properties in Mice. Bioconjugate Chemistry
Liu YA, Jin Q, Zou Y, et al. (2020) Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133. Journal of Medicinal Chemistry
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