Oscar Huang

Early Discovery Biochemistry Genentech, Inc., San Francisco, CA, United States 
"Oscar Huang"
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Taylor AM, Côté A, Hewitt MC, et al. (2016) Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Acs Medicinal Chemistry Letters. 7: 531-536
Flynn EM, Huang OW, Poy F, et al. (2015) A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications. Structure (London, England : 1993)
Taherbhoy AM, Huang OW, Cochran AG. (2015) BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. Nature Communications. 6: 7621
Rutz S, Kayagaki N, Phung QT, et al. (2015) Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 518: 417-21
Huang OW, Cochran AG. (2013) Regulation of deubiquitinase proteolytic activity. Current Opinion in Structural Biology. 23: 806-11
Huang OW, Ma X, Yin J, et al. (2012) Phosphorylation-dependent activity of the deubiquitinase DUBA Nature Structural and Molecular Biology. 19: 171-176
Bourhis E, Wang W, Tam C, et al. (2011) Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6. Structure (London, England : 1993). 19: 1433-42
Aliagas-Martin I, Burdick D, Corson L, et al. (2009) A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. Journal of Medicinal Chemistry. 52: 3300-7
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