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E Megan Flynn

Affiliations: 
Early Discovery Biochemistry Genentech, Inc., San Francisco, CA, United States 
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Andrea G. Cochran research assistant Genentech, Inc.

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Miller GM, Flynn EM, Tom J, et al. (2022) Trifluoroacetyl Lysine as a Bromodomain Binding Mimic of Lysine Acetylation. Acs Chemical Biology
Wang S, Tsui V, Crawford TD, et al. (2018) GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like. Journal of Medicinal Chemistry
Raisner R, Kharbanda S, Jin L, et al. (2018) Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation. Cell Reports. 24: 1722-1729
Oppikofer M, Sagolla M, Haley B, et al. (2017) Non-canonical reader modules of BAZ1A promote recovery from DNA damage. Nature Communications. 8: 862
Crawford TD, Audia JE, Bellon S, et al. (2017) GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2). Acs Medicinal Chemistry Letters. 8: 737-741
Crawford TD, Vartanian S, Côté A, et al. (2017) Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance. Bioorganic & Medicinal Chemistry Letters
Crawford TD, Tsui V, Flynn EM, et al. (2016) Diving into the water: Inducible binding conformations for BRD4, TAF1(2), BRD9, and CECR2 bromodomains. Journal of Medicinal Chemistry
Vinogradova M, Gehling VS, Gustafson A, et al. (2016) An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nature Chemical Biology
Taylor AM, Côté A, Hewitt MC, et al. (2016) Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Acs Medicinal Chemistry Letters. 7: 531-536
Flynn EM, Huang OW, Poy F, et al. (2015) A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications. Structure (London, England : 1993)
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