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Mugdha Patki, Ph.D.

Affiliations: 
2013 College of Medicine The University of Toledo 
Area:
Biochemistry, Endocrinology Biology
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Manohar Ratnam grad student 2013 The University of Toledo
 (Novel Actions of Steroid Receptors that Limit Treatment Response in Breast and Lung Cancers.)

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Publications

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Patki M, McFall T, Rosati R, et al. (2018) Chronic p27 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor. Scientific Reports. 8: 16006
Rosati R, Patki M, Chari V, et al. (2016) The Amino-terminal Domain of the Androgen Receptor Co-opts ERK Docking Sites in ELK1 to Induce Sustained Gene Activation that Supports Prostate Cancer Cell Growth. The Journal of Biological Chemistry
Rosati R, Chen B, Patki M, et al. (2016) Hybrid Enzalutamide Derivatives with Histone Deacetylase Inhibitor Activity Decrease HSP90 and the Androgen Receptor Levels and Inhibit Viability in Enzalutamide Resistant C4-2 Prostate Cancer Cells. Molecular Pharmacology
Patki M, Huang Y, Ratnam M. (2016) Restoration of the cellular secretory milieu overrides androgen dependence of in vivo generated castration resistant prostate cancer cells overexpressing the androgen receptor. Biochemical and Biophysical Research Communications
Patki M, Huang Y, Ratnam M. (2016) Abstract LB-256: Clonogenic growth of androgen receptor-overexpressing models of castration recurrent prostate cancer cells becomes insensitive to receptor ligands when their complete cellular secretory milieu is restored Cancer Research. 76
Rosati R, Patki M, Dakshnamurthy S, et al. (2016) Abstract 2876: The androgen receptor utilizes protein kinase docking sites to constitutively activate Elk1 Cancer Research. 76: 2876-2876
Patki M, Huang Y, Wilson M, et al. (2016) Long-term treatment with dexamethasone induces senescence and progressive loss of proliferation potential in lung adenocarcinoma cells expressing high levels of the glucocorticoid receptor Journal of Thoracic Oncology. 11: S36
McFall T, Patki M, Rosati R, et al. (2015) Role of the short isoform of the progesterone receptor in breast cancer cell invasiveness at estrogen and progesterone levels in the pre- and post-menopausal ranges. Oncotarget. 6: 33146-64
Patki M, Salazar Md, Trumbly R, et al. (2015) Differential effects of estrogen-dependent transactivation vs. transrepression by the estrogen receptor on invasiveness of HER2 overexpressing breast cancer cells. Biochemical and Biophysical Research Communications. 457: 404-11
McFall T, Patki M, Rosati R, et al. (2015) Role of the short isoform of the progesterone receptor in breast cancer cell invasiveness at estrogen and progesterone levels in the pre- and post-menopausal ranges Oncotarget. 6: 33146-33164
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