Aaron Shatkin

Affiliations: 
Rutgers University, New Brunswick, New Brunswick, NJ, United States 
Area:
Molecular Biology
Website:
http://www.nasonline.org/member-directory/deceased-members/50565.html
Google:
"Aaron J. Shatkin"
Bio:

(1934 - 2012)
http://dx.doi.org/10.1073/pnas.1215048109
http://dx.doi.org/10.1126/science.1226820

Discovered the 5'cap, which is present at the beginning of eukaryotic mRNAs.

Mean distance: 9.39
 
SNBCP
Cross-listing: Cell Biology Tree - DevTree

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Publications

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Bauman JD, Patel D, Dharia C, et al. (2013) Detecting allosteric sites of HIV-1 reverse transcriptase by X-ray crystallographic fragment screening. Journal of Medicinal Chemistry. 56: 2738-46
Topisirovic I, Svitkin YV, Sonenberg N, et al. (2011) Cap and cap-binding proteins in the control of gene expression. Wiley Interdisciplinary Reviews. Rna. 2: 277-98
Chu C, Das K, Tyminski JR, et al. (2011) Structure of the guanylyltransferase domain of human mRNA capping enzyme. Proceedings of the National Academy of Sciences of the United States of America. 108: 10104-8
Shatkin A, Das K, Arnold E. (2008) 3D jigsaw puzzle in rotavirus assembly. Structure (London, England : 1993). 16: 1601-2
Liu D, Fritz DT, Rogers MB, et al. (2008) Species-specific cis-regulatory elements in the 3'-untranslated region direct alternative polyadenylation of bone morphogenetic protein 2 mRNA. The Journal of Biological Chemistry. 283: 28010-9
Chu C, Shatkin AJ. (2008) Apoptosis and autophagy induction in mammalian cells by small interfering RNA knockdown of mRNA capping enzymes. Molecular and Cellular Biology. 28: 5829-36
Bauman JD, Das K, Ho WC, et al. (2008) Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Nucleic Acids Research. 36: 5083-92
Das K, Bauman JD, Clark AD, et al. (2008) High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations. Proceedings of the National Academy of Sciences of the United States of America. 105: 1466-71
Kaneko S, Chu C, Shatkin AJ, et al. (2007) Human capping enzyme promotes formation of transcriptional R loops in vitro. Proceedings of the National Academy of Sciences of the United States of America. 104: 17620-5
Shafer B, Chu C, Shatkin AJ. (2005) Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability. Molecular and Cellular Biology. 25: 2644-9
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