Christopher C. Kloss, Ph.D.

2013 Weill Cornell Medical College, New York, NY, United States 
Inorganic Chemistry, Oncology, Biomedical Engineering
"Christopher Kloss"
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Michel Sadelcuh grad student 2013 Weill Cornell Medical College
 (Generation of chimeric antigen receptor modified human T lymphocytes for the potent and dual-antigen selective eradication of human cancers in mice.)
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Ramalingam P, Poulos MG, Lazzari E, et al. (2020) Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF. Nature Communications. 11: 666
Castellarin M, Watanabe K, June CH, et al. (2018) Driving cars to the clinic for solid tumors. Gene Therapy
Wertheimer T, Velardi E, Tsai J, et al. (2018) Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration. Science Immunology. 3
Zhao Z, Condomines M, van der Stegen SJ, et al. (2015) Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells. Cancer Cell. 28: 415-28
Johnson LA, Scholler J, Ohkuri T, et al. (2015) Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma. Science Translational Medicine. 7: 275ra22
Poulos MG, Gars EJ, Gutkin MC, et al. (2014) Activation of the vascular niche supports leukemic progression and resistance to chemotherapy. Experimental Hematology. 42: 976-86.e1-3
Fedorov VD, Sadelain M, Kloss CC. (2014) Novel approaches to enhance the specificity and safety of engineered T cells. Cancer Journal (Sudbury, Mass.). 20: 160-5
Wertheimer T, Kloss CC, Velardi E, et al. (2014) Endothelial Cells Promote Endogenous Thymic Regeneration after Injury Via BMP4 Signaling Blood. 124: 2429-2429
Themeli M, Kloss CC, Ciriello G, et al. (2013) Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy. Nature Biotechnology. 31: 928-33
Davila ML, Kloss CC, Gunset G, et al. (2013) CD19 CAR-targeted T cells induce long-term remission and B Cell Aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia. Plos One. 8: e61338
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