Dale F. Mierke, Ph.D.

Affiliations: 
Chemistry Dartmouth College, Hanover, NH, United States 
Area:
Biophysical chemistry, high resolution NMR, peptide hormone structure and function
Website:
http://www.dartmouth.edu/~chem/faculty/dfm.html
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"Dale Mierke"
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SNBCP

Parents

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Murray Goodman grad student 1988 UCSD
 (Nuclear magnetic resonance studies and computer simulations of biologically active peptides)
Horst C. Kessler post-doc 1990-1993 Technical University Munich

Children

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Alexander E. Kelly research assistant 1998 Clark University (Cell Biology Tree)
Christopher O. Audu grad student 2013 Dartmouth
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Publications

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Gaidos G, Panaitiu AE, Guo B, et al. (2015) Identification and Characterization of the Interaction Site between cFLIPL and Calmodulin. Plos One. 10: e0141692
Li W, Zheng S, Higgins M, et al. (2015) New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase. Journal of Medicinal Chemistry. 58: 4738-48
Bucur O, Gaidos G, Yatawara A, et al. (2015) A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death. Scientific Reports. 5: 9893
Yatawara A, Gaidos G, Rupasinghe CN, et al. (2015) Small-molecule inhibitors of JC polyomavirus infection. Journal of Peptide Science : An Official Publication of the European Peptide Society. 21: 236-42
Song GJ, Leslie KL, Barrick S, et al. (2015) Phosphorylation of ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) by Akt promotes stability and mitogenic function of S-phase kinase-associated protein-2 (Skp2). The Journal of Biological Chemistry. 290: 2879-87
Zheng F, Jewell H, Fitzpatrick J, et al. (2015) Computational design of selective peptides to discriminate between similar PDZ domains in an oncogenic pathway. Journal of Molecular Biology. 427: 491-510
Yu J, Rupasinghe C, Wilson JL, et al. (2015) Targeting receptor tyrosine kinases and their downstream signaling with cell-penetrating peptides in human pulmonary artery smooth muscle and endothelial cells. Chemical Biology & Drug Design. 85: 586-97
Guo B, Audu CO, Cochran JC, et al. (2014) Protein engineering of the N-terminus of NEMO: structure stabilization and rescue of IKKβ binding. Biochemistry. 53: 6776-85
Fitzpatrick JM, Pellegrini M, Cushing PR, et al. (2014) Small molecule inhibition of the Na(+)/H(+) exchange regulatory factor 1 and parathyroid hormone 1 receptor interaction. Biochemistry. 53: 5916-22
Guo B, Gurel PS, Shu R, et al. (2014) Monitoring ATP hydrolysis and ATPase inhibitor screening using (1)H NMR. Chemical Communications (Cambridge, England). 50: 12037-9
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