Luciana E. Giono, Ph.D.

Affiliations: 
2006 Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
Molecular Biology, Cell Biology
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"Luciana Giono"
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James J. Manfredi grad student 2006 Mount Sinai School of Medicine
 (Role of p53 transcriptional regulation in cell cycle checkpoints.)
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Publications

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Giono LE, Resnick-Silverman L, Carvajal LA, et al. (2017) Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase. Oncogene
Carcagno AL, Giono LE, Marazita MC, et al. (2012) E2F1 induces p19INK4d, a protein involved in the DNA damage response, following UV irradiation. Molecular and Cellular Biochemistry. 366: 123-9
Carcagno AL, Marazita MC, Ogara MF, et al. (2011) E2F1-mediated upregulation of p19INK4d determines its periodic expression during cell cycle and regulates cellular proliferation. Plos One. 6: e21938
Giono LE, Manfredi JJ. (2007) Mdm2 plays a positive role as an effector of p53-dependent responses. Cell Cycle (Georgetown, Tex.). 6: 2143-7
Giono LE, Manfredi JJ. (2007) Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest. Molecular and Cellular Biology. 27: 4166-78
Giono LE, Manfredi JJ. (2006) The p53 tumor suppressor participates in multiple cell cycle checkpoints. Journal of Cellular Physiology. 209: 13-20
St Clair S, Giono L, Varmeh-Ziaie S, et al. (2004) DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter. Molecular Cell. 16: 725-36
Narla G, Heath KE, Reeves HL, et al. (2001) KLF6, a candidate tumor suppressor gene mutated in prostate cancer. Science (New York, N.Y.). 294: 2563-6
GARCÍA-MONTERO AC, VASSEUR S, GIONO LE, et al. (2001) Transforming growth factor β-1 enhances Smad transcriptional activity through activation of p8 gene expression Biochemical Journal. 357: 249-253
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