Philip Hanoian, Ph.D.

Affiliations: 
2014 Pennsylvania State University, State College, PA, United States 
Area:
Molecular Chemistry
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"Philip Hanoian"
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William George Noid grad student 2014 Penn State
 (Computer simulations of enzymes.)
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Publications

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Hanoian P, Liu CT, Hammes-Schiffer S, et al. (2015) Perspectives on electrostatics and conformational motions in enzyme catalysis. Accounts of Chemical Research. 48: 482-9
Liu CT, Layfield JP, Stewart RJ, et al. (2014) Probing the electrostatics of active site microenvironments along the catalytic cycle for Escherichia coli dihydrofolate reductase. Journal of the American Chemical Society. 136: 10349-60
Schwans JP, Hanoian P, Lengerich BJ, et al. (2014) Experimental and computational mutagenesis to investigate the positioning of a general base within an enzyme active site. Biochemistry. 53: 2541-55
Liu CT, Hanoian P, French JB, et al. (2013) Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans. Proceedings of the National Academy of Sciences of the United States of America. 110: 10159-64
Hanoian P, Hammes-Schiffer S. (2011) Water in the active site of ketosteroid isomerase. Biochemistry. 50: 6689-700
Hanoian P, Sigala PA, Herschlag D, et al. (2010) Hydrogen bonding in the active site of ketosteroid isomerase: electronic inductive effects and hydrogen bond coupling. Biochemistry. 49: 10339-48
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