Colette T. Dooley, Ph.D

Torrey Pines Institute for Molecular Studies, USA 
GPCRs, Opioids, Combinatorial chemistry, Oxidative Stress
"Colette Dooley"
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Roger Y. Tsien grad student 2000-2006 UCSD
 (Green fluorescent protein based indicators of dynamic redox changes and reactive oxygen species.)
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Li Y, Cazares M, Wu J, et al. (2016) Potent Mu-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological and Structural Evaluation. Journal of Medicinal Chemistry
Houghten RA, Ganno ML, McLaughlin JP, et al. (2015) Direct High Throughput In Vivo Screening: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine bis-Piperazines. Acs Combinatorial Science
Eans SO, Ganno ML, Mizrachi E, et al. (2015) Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors. Journal of Medicinal Chemistry. 58: 4905-17
Hu M, Giulianotti MA, McLaughlin JP, et al. (2015) Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities. European Journal of Medicinal Chemistry. 92: 270-81
Hammami S, Mighri Z, Dooley CT, et al. (2014) Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin. Bioorganic & Medicinal Chemistry Letters. 24: 4482-5
Martinez-Mayorga K, Byler KG, Yongye AB, et al. (2013) Ligand/kappa-opioid receptor interactions: insights from the X-ray crystal structure. European Journal of Medicinal Chemistry. 66: 114-21
Murru S, Dooley CT, Nefzi A. (2013) Parallel synthesis of bis-oxazole peptidomimetics Tetrahedron Letters. 54: 7062-7064
Li Y, Dooley CT, Misler JA, et al. (2012) Fluorescent mu selective opioid ligands from a mixture based cyclic peptide library. Acs Combinatorial Science. 14: 673-9
Giulianotti MA, Debevec G, Santos RG, et al. (2012) A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries. Acs Combinatorial Science. 14: 503-12
Dooley CT, Li L, Misler JA, et al. (2012) Toxicity of 6-hydroxydopamine: live cell imaging of cytoplasmic redox flux. Cell Biology and Toxicology. 28: 89-101
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