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Felicia A. Etzkorn, Ph.D.

Affiliations: 
1993-2000 Chemistry University of Virginia, Charlottesville, VA 
 2000- Chemistry Virginia Polytechnic Institute and State University, Blacksburg, VA, United States 
Area:
protein structure and enzyme inhibitors by designing and synthesizing conformationally constrained mimics of peptides
Website:
http://www.etzkornlab.chem.vt.edu/
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"Felicia Etzkorn"
Bio:

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Mean distance: 7.16
 
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Parents

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James F. Hinton research assistant 1977 University of Arkansas, Fayetteville
Paul Allan Bartlett grad student 1991 UC Berkeley
 (Design, synthesis and evaluation of tendamistat mimics : inhibitors of a-amylase)
Christopher T. Walsh post-doc 1991-1993 Harvard Medical School

Children

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Luke Wiseman research assistant 2000 UVA
Jennifer L. Stockdill research assistant 2001-2002 Virginia Tech
Matthew D. Shoulders research assistant 2004 Virginia Tech
Scott A. Hart grad student 2000 UVA
Tobin J. Dickerson grad student 1999-2000 UVA
Tao Liu grad student 2007 Virginia Tech
Song Zhao grad student 2007 Virginia Tech
Nan Dai grad student 2008 Virginia Tech
Galina Kapustina post-doc 2000-2003 Virginia Tech
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Publications

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Mayfield JE, Fan S, Wei S, et al. (2015) Chemical Tools To Decipher Regulation of Phosphatases by Proline Isomerization on Eukaryotic RNA Polymerase II. Acs Chemical Biology
Etzkorn FA, Zhao S. (2015) Stereospecific phosphorylation by the central mitotic kinase Cdk1-cyclin B. Acs Chemical Biology. 10: 952-6
Mercedes-Camacho AY, Mullins AB, Mason MD, et al. (2013) Kinetic isotope effects support the twisted amide mechanism of Pin1 peptidyl-prolyl isomerase. Biochemistry. 52: 7707-13
Nachman RJ, Wang XJ, Etzkorn FA, et al. (2013) Evaluation of insect CAP2b analogs with either an (E)-alkene, trans- or a (Z)-alkene, cis-Pro isostere identifies the Pro orientation for antidiuretic activity in the stink bug. Peptides. 41: 101-6
Xu GG, Slebodnick C, Etzkorn FA. (2012) Cyclohexyl ketone inhibitors of Pin1 dock in a trans-diaxial cyclohexane conformation. Plos One. 7: e44226
Zhang M, Wang XJ, Chen X, et al. (2012) Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code. Acs Chemical Biology. 7: 1462-70
Tarrant MK, Rho HS, Xie Z, et al. (2012) Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Nature Chemical Biology. 8: 262-9
Xu GG, Zhang Y, Mercedes-Camacho AY, et al. (2011) A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state. Biochemistry. 50: 9545-50
Namanja AT, Wang XJ, Xu B, et al. (2011) Stereospecific gating of functional motions in Pin1. Proceedings of the National Academy of Sciences of the United States of America. 108: 12289-94
Namanja AT, Wang XJ, Xu B, et al. (2010) Toward flexibility-activity relationships by NMR spectroscopy: dynamics of Pin1 ligands. Journal of the American Chemical Society. 132: 5607-9
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