A. James Link, Ph.D.

chemical and biological engineering Princeton University, Princeton, NJ 
protein engineering, natural products
"A. James Link"


Mean distance: 8.73


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David A. Tirrell grad student 2000-2005 Caltech
 (Azide-bearing amino acids in protein engineering and proteomic profiling)
George Georgiou post-doc 2007 UT Austin


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Si J. Pan grad student 2012 Princeton
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Cheung-Lee WL, Parry ME, Jaramillo Cartagena A, et al. (2019) Discovery and structure of the antimicrobial lasso peptide citrocin. The Journal of Biological Chemistry
Braffman NR, Piscotta FJ, Hauver J, et al. (2019) Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proceedings of the National Academy of Sciences of the United States of America. 116: 1273-1278
Piscotta FJ, Jeffrey PD, Link AJ. (2019) ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism. Proceedings of the National Academy of Sciences of the United States of America. 116: 826-834
Koos JD, Link AJ. (2018) Heterologous and in vitro reconstitution of fuscanodin, a lasso peptide from Thermobifida fusca. Journal of the American Chemical Society
Elashal HE, Cohen RD, Elashal HE, et al. (2018) Cyclic and Lasso Peptides: Sequence Determination, Topology Analysis, and Rotaxane Formation. Angewandte Chemie (International Ed. in English)
Zong C, Cheung-Lee WL, Elashal HE, et al. (2018) Albusnodin: an acetylated lasso peptide from Streptomyces albus. Chemical Communications (Cambridge, England)
Zong C, Wu MJ, Qin JZ, et al. (2017) Lasso peptide benenodin-1 is a thermally actuated [1]rotaxane switch. Journal of the American Chemical Society
Chekan JR, Koos JD, Zong C, et al. (2016) Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates. Journal of the American Chemical Society. 138: 16452-16458
Cheung WL, Chen MY, Maksimov MO, et al. (2016) Lasso Peptide Biosynthetic Protein LarB1 Binds Both Leader and Core Peptide Regions of the Precursor Protein LarA. Acs Central Science. 2: 702-709
Allen CD, Link AJ. (2016) Self-Assembly of Catenanes from Lasso Peptides. Journal of the American Chemical Society
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