Barbara Ramsay Shaw

Affiliations: 
Chemistry Duke University, Durham, NC 
Area:
Boronated Nucleic Acids
Website:
http://www.chem.duke.edu/~brs/labgroup/shaw.html
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"Barbara Shaw"
Bio:

http://cnc-acs.sites.acs.org/WCC%20Flyer%20SERMACS%202012.pdf

Mean distance: 8.48
 
SNBCP

Parents

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Walter Kauzmann grad student Princeton
 (visiting graduate student)
J. Michael Schurr grad student 1973 University of Washington
 (Collagen model polypeptides (Pro-Pro-Gly)n ;--synthesis and thermal transitions)

Children

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Loren Dean Williams grad student 1985 Duke
Kaizhang He grad student 2000 Duke
Mark A. Zottola grad student 2000 Duke
Jinlai Lin grad student 2001 Duke
Joy X. Wang grad student 2004 Duke
Jing Wan grad student 2005 Duke
Hongyan Liu grad student 2007 Duke
Charlotta K. Wennefors grad student 2008 Duke
Laura W. Moussa grad student 2009 Duke
Marcus A. Cheek grad student 2011 Duke
Mariam L. Sharaf grad student 2011 Duke
BETA: Related publications

Publications

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Xu Z, Shaw BR. (2015) Synthesis, Hydrolysis, and Protonation-Promoted Intramolecular Reductive Breakdown of Potential NRTIs: Stavudine α-P-Borano-γ-P-N-l-tryptophanyltriphosphates. Molecules (Basel, Switzerland). 20: 18808-18826
Xu Z, Shaw BR. (2014) Phosphorus deprotonation by a non-nucleophilic base is critical for the synthesis of nucleoside α-P-boranodiphosphates via a phosphoramidite approach Tetrahedron Letters. 55: 5605-5608
Cheek MA, Sharaf ML, Dobrikov MI, et al. (2013) Inhibition of hepatitis C viral RNA-dependent RNA polymerase by α-P-boranophosphate nucleotides: exploring a potential strategy for mechanism-based HCV drug design. Antiviral Research. 98: 144-52
Xu Z, Sergueeva ZA, Shaw BR. (2013) Synthesis and hydrolytic properties of thymidine boranomonophosphate Tetrahedron Letters. 54: 2882-2885
Ray P, Cheek MA, Sharaf ML, et al. (2012) Aptamer-mediated delivery of chemotherapy to pancreatic cancer cells. Nucleic Acid Therapeutics. 22: 295-305
Johnson CN, Spring AM, Sergueev D, et al. (2011) Structural basis of the RNase H1 activity on stereo regular borano phosphonate DNA/RNA hybrids. Biochemistry. 50: 3903-12
Shaw BR, Moussa L, Sharaf M, et al. (2008) Boranophosphate siRNA-aptamer chimeras for tumor-specific downregulation of cancer receptors and modulators. Nucleic Acids Symposium Series (2004). 655-6
Cheek MA, Dobrikov MI, Wennefors CK, et al. (2008) Synthesis and properties of (alpha-P-borano)-nucleoside 5'-triphosphate analogues as potential antiviral agents. Nucleic Acids Symposium Series (2004). 81-2
Wennefors CK, Dobrikov MI, Xu Z, et al. (2008) Stereospecificity, substrate, and inhibitory properties of nucleoside diphosphate analogs for creatine and pyruvate kinases. Bioorganic Chemistry. 36: 169-77
Khan SI, Shaw BR. (2007) Efficient synthesis of thymidine boranophosphoramidates conjugated with amino acids. Nucleosides, Nucleotides & Nucleic Acids. 26: 621-3
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