☰ Chemistry Tree

Arun Radhakrishnan

Affiliations:

Molecular Genetics

University of Texas Southwestern Medical Center, Dallas, TX, United States

Area:

Regulation of cellular cholesterol, Protein sensors for membrane cholesterol and sphingomyelin

Website:

http://www.utsouthwestern.edu/fis/faculty/57962/arun-radhakrishnan.html

Google:

"Arun Radhakrishnan"

Bio:

http://searchworks-lb.stanford.edu/view/5416076

Mean distance: 7.75

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Parents

Harden M. McConnell	grad student	2002	Stanford
(Condensed complexes and the chemical activity of cholesterol in membranes.)
Michael Stuart Brown	post-doc		UT Southwestern

Children

Austin Gay	grad student	2012-2016	UT Southwestern
Shreya Endapally	grad student	2013-2019	UT Southwestern
Kristen A. Johnson	post-doc	2018-	UT Southwestern

Collaborators

BETA: Related publications

Publications

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Xu S, Donnelly L, Kober DL, et al. (2024) Development of a monoclonal antibody to study MARCH6, an E3 ligase that regulates proteins that control lipid homeostasis. Journal of Lipid Research. 100650
Xu S, Smothers JC, Rye D, et al. (2024) A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells. Proceedings of the National Academy of Sciences of the United States of America. 121: e2318024121
Heisler DB, Johnson KA, Ma DH, et al. (2023) A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection. Elife. 12
Kinnebrew M, Johnson KA, Radhakrishnan A, et al. (2022) Measuring and Manipulating Membrane Cholesterol for the Study of Hedgehog Signaling. Methods in Molecular Biology (Clifton, N.J.). 2374: 73-87
Kinnebrew M, Luchetti G, Sircar R, et al. (2021) Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes. Elife. 10
Kober DL, Radhakrishnan A, Goldstein JL, et al. (2021) Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing. Cell
Johnson KA, Radhakrishnan A. (2021) The use of anthrolysin O and ostreolysin A to study cholesterol in cell membranes. Methods in Enzymology. 649: 543-566
Abrams ME, Johnson KA, Radhakrishnan A, et al. (2020) Accessible cholesterol is localized in bacterial plasma membrane protrusions. Journal of Lipid Research. 61: 1538
Radhakrishnan A, Rohatgi R, Siebold C. (2020) Cholesterol access in cellular membranes controls Hedgehog signaling. Nature Chemical Biology. 16: 1303-1313
Kober DL, Xu S, Li S, et al. (2020) Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis. Proceedings of the National Academy of Sciences of the United States of America

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