Arun Radhakrishnan
Affiliations: | Molecular Genetics | University of Texas Southwestern Medical Center, Dallas, TX, United States |
Area:
Regulation of cellular cholesterol, Protein sensors for membrane cholesterol and sphingomyelinWebsite:
http://www.utsouthwestern.edu/fis/faculty/57962/arun-radhakrishnan.htmlGoogle:
"Arun Radhakrishnan"Bio:
http://searchworks-lb.stanford.edu/view/5416076
Mean distance: 7.75 | S | N | B | C | P |
Parents
Sign in to add mentorHarden M. McConnell | grad student | 2002 | Stanford | |
(Condensed complexes and the chemical activity of cholesterol in membranes.) | ||||
Michael Stuart Brown | post-doc | UT Southwestern |
Children
Sign in to add traineeAustin Gay | grad student | 2012-2016 | UT Southwestern |
Shreya Endapally | grad student | 2013-2019 | UT Southwestern |
Kristen A. Johnson | post-doc | 2018- | UT Southwestern |
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Publications
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Xu S, Smothers JC, Rye D, et al. (2024) A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells. Proceedings of the National Academy of Sciences of the United States of America. 121: e2318024121 |
Heisler DB, Johnson KA, Ma DH, et al. (2023) A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection. Elife. 12 |
Kinnebrew M, Johnson KA, Radhakrishnan A, et al. (2022) Measuring and Manipulating Membrane Cholesterol for the Study of Hedgehog Signaling. Methods in Molecular Biology (Clifton, N.J.). 2374: 73-87 |
Kinnebrew M, Luchetti G, Sircar R, et al. (2021) Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes. Elife. 10 |
Kober DL, Radhakrishnan A, Goldstein JL, et al. (2021) Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing. Cell |
Johnson KA, Radhakrishnan A. (2021) The use of anthrolysin O and ostreolysin A to study cholesterol in cell membranes. Methods in Enzymology. 649: 543-566 |
Abrams ME, Johnson KA, Radhakrishnan A, et al. (2020) Accessible cholesterol is localized in bacterial plasma membrane protrusions. Journal of Lipid Research. 61: 1538 |
Radhakrishnan A, Rohatgi R, Siebold C. (2020) Cholesterol access in cellular membranes controls Hedgehog signaling. Nature Chemical Biology. 16: 1303-1313 |
Kober DL, Xu S, Li S, et al. (2020) Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis. Proceedings of the National Academy of Sciences of the United States of America |
Abrams ME, Johnson KA, Radhakrishnan A, et al. (2020) Accessible cholesterol is localized in bacterial plasma membrane protrusions. Journal of Lipid Research |