Karen Marie Vasquez, Ph.D.

Pharmacology & Toxicology University of Texas at Austin, Austin, Texas, U.S.A. 
DNA damage and repair, genomic instability, gene targeting, DNA structure, cancer therapeutics Current Research
"Karen Vasquez UT"

1996 Baylor College of Medicine, Houston, TX, Doctor of Philosophy, Biochemistry

1987 University of Miami, Coral Gables, FL, BS, Biology, Marine Science Postgraduate Training

1997-2000 Postdoctoral Fellowship, Yale University School of Medicine, Department of Therapeutic Radiology, New Haven, CT

1996-1997 Postdoctoral Associate, Baylor College of Medicine, Deparment of Biochemistry, Houston, TX Experience/Service
Current Appointments:

Professor and Coulter R. Sublett Fellow The University of Texas at Austin Division of Pharmacology and Toxicology College of Pharmacy Dell Pediatric Research Institute

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Bacolla A, Wang G, Vasquez KM. (2015) New Perspectives on DNA and RNA Triplexes As Effectors of Biological Activity. Plos Genetics. 11: e1005696
Khandelwal A, Bacolla A, Vasquez KM, et al. (2015) Long non-coding RNA: A new paradigm for lung cancer. Molecular Carcinogenesis
Temiz NA, Donohue DE, Bacolla A, et al. (2015) The somatic autosomal mutation matrix in cancer genomes. Human Genetics. 134: 851-64
Bacolla A, Zhu X, Chen H, et al. (2015) Local DNA dynamics shape mutational patterns of mononucleotide repeats in human genomes. Nucleic Acids Research. 43: 5065-80
Lu S, Wang G, Bacolla A, et al. (2015) Short Inverted Repeats Are Hotspots for Genetic Instability: Relevance to Cancer Genomes. Cell Reports
Wang G, Vasquez KM. (2014) Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability. Dna Repair. 19: 143-51
Bacolla A, Cooper DN, Vasquez KM. (2014) Mechanisms of base substitution mutagenesis in cancer genomes. Genes. 5: 108-46
Boulware SB, Christensen LA, Thames H, et al. (2014) Triplex-forming oligonucleotides targeting c-MYC potentiate the anti-tumor activity of gemcitabine in a mouse model of human cancer. Molecular Carcinogenesis. 53: 744-52
Bacolla A, Temiz NA, Yi M, et al. (2013) Guanine holes are prominent targets for mutation in cancer and inherited disease. Plos Genetics. 9: e1003816
Jain A, Bacolla A, Del Mundo IM, et al. (2013) DHX9 helicase is involved in preventing genomic instability induced by alternatively structured DNA in human cells. Nucleic Acids Research. 41: 10345-57
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