Jonathan K. Watts, Ph.D.

2012-2015 Chemistry University of Southampton, Southampton, England, United Kingdom 
 2015- RNA Therapeutics Institute UMass Chan Medical School 
Nucleic Acid Therapeutics, Chemical Biology
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Masad J. Damha grad student 2002-2008 McGill
David R. Corey post-doc 2008-2012 UT Southwestern
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Goddard LR, Mardle CE, Gneid H, et al. (2021) An Investigation into the Potential of Targeting mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy. Molecules (Basel, Switzerland). 26
Price DA, Kartje ZJ, Hughes JA, et al. (2020) Infrared Spectroscopy Reveals the Preferred Motif Size and Local Disorder in Parallel Stranded DNA G-quadruplexes. Chembiochem : a European Journal of Chemical Biology
Wang F, Zuroske T, Watts JK. (2020) RNA therapeutics on the rise. Nature Reviews. Drug Discovery
Watts JK, Ockene IS. (2020) RNA Interference for the Masses? siRNA Targeting PCSK9 Promises Prevention of Cardiovascular Disease. Nucleic Acid Therapeutics
Debacker AJ, Sharma VK, Meda Krishnamurthy P, et al. (2018) Next-generation PNA chimeras exhibit high affinity and potent gene silencing. Biochemistry
Mir A, Alterman JF, Hassler MR, et al. (2018) Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing. Nature Communications. 9: 2641
Li L, Shen X, Liu Z, et al. (2018) Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat. Nucleic Acid Therapeutics
Hu J, Rong Z, Gong X, et al. (2018) Oligonucleotides Targeting TCF4 Triplet Repeat Expansion Inhibit RNA Foci and Mis-splicing in Fuchs' Dystrophy. Human Molecular Genetics
Pendergraff HM, Krishnamurthy PM, Debacker AJ, et al. (2017) Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA. Molecular Therapy. Nucleic Acids. 8: 158-168
Pendergraff HM, Debacker AJ, Watts JK. (2016) Single-Stranded Silencing RNAs: Hit Rate and Chemical Modification. Nucleic Acid Therapeutics
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