Jonathan K. Watts, Ph.D.

2012-2015 Chemistry University of Southampton, Southampton, England, United Kingdom 
 2015- RNA Therapeutics Institute UMass Chan Medical School 
Nucleic Acid Therapeutics, Chemical Biology
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Masad J. Damha grad student 2002-2008 McGill
David R. Corey post-doc 2008-2012 UT Southwestern
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Shah S, Sharp KJ, Raju Ponny S, et al. (2023) Antisense oligonucleotide rescue of CGG expansion-dependent mis-splicing in fragile X syndrome restores FMRP. Proceedings of the National Academy of Sciences of the United States of America. 120: e2302534120
Zhang H, Kelly K, Lee J, et al. (2023) Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing . Biorxiv : the Preprint Server For Biology
Hariharan VN, Shin M, Chang CW, et al. (2023) Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219523120
Wang F, Calvo-Roitberg E, Rembetsy-Brown JM, et al. (2022) G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects. Nucleic Acids Research
Goddard LR, Mardle CE, Gneid H, et al. (2021) An Investigation into the Potential of Targeting mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy. Molecules (Basel, Switzerland). 26
Price DA, Kartje ZJ, Hughes JA, et al. (2020) Infrared Spectroscopy Reveals the Preferred Motif Size and Local Disorder in Parallel Stranded DNA G-quadruplexes. Chembiochem : a European Journal of Chemical Biology
Wang F, Zuroske T, Watts JK. (2020) RNA therapeutics on the rise. Nature Reviews. Drug Discovery
Watts JK, Ockene IS. (2020) RNA Interference for the Masses? siRNA Targeting PCSK9 Promises Prevention of Cardiovascular Disease. Nucleic Acid Therapeutics
Debacker AJ, Sharma VK, Meda Krishnamurthy P, et al. (2018) Next-generation PNA chimeras exhibit high affinity and potent gene silencing. Biochemistry
Mir A, Alterman JF, Hassler MR, et al. (2018) Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing. Nature Communications. 9: 2641
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