Gary Coombs

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1993-1998 Biochemistry Waldorf College 
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"Gary Coombs"
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Bergstrom RC, Coombs GS, Ye S, et al. (2003) Binding of nonphysiological protein and peptide substrates to proteases: differences between urokinase-type plasminogen activator and trypsin and contributions to the evolution of regulated proteolysis. Biochemistry. 42: 5395-402
Zeslawska E, Jacob U, Schweinitz A, et al. (2003) Crystals of urokinase type plasminogen activator complexes reveal the binding mode of peptidomimetic inhibitors. Journal of Molecular Biology. 328: 109-18
Friedrich R, Fuentes-Prior P, Ong E, et al. (2002) Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. The Journal of Biological Chemistry. 277: 2160-8
Hervio LS, Coombs GS, Bergstrom RC, et al. (2000) Negative selectivity and the evolution of protease cascades: the specificity of plasmin for peptide and protein substrates. Chemistry & Biology. 7: 443-53
Coombs GS, Rao MS, Olson AJ, et al. (1999) Revisiting catalysis by chymotrypsin family serine proteases using peptide substrates and inhibitors with unnatural main chains. The Journal of Biological Chemistry. 274: 24074-9
Coombs GS, Bergstrom RC, Pellequer JL, et al. (1998) Substrate specificity of prostate-specific antigen (PSA). Chemistry & Biology. 5: 475-88
Coombs GS, Bergstrom RC, Madison EL, et al. (1998) Directing sequence-specific proteolysis to new targets. The influence of loop size and target sequence on selective proteolysis by tissue-type plasminogen activator and urokinase-type plasminogen activator. The Journal of Biological Chemistry. 273: 4323-8
Ke SH, Coombs GS, Tachias K, et al. (1997) Optimal subsite occupancy and design of a selective inhibitor of urokinase. The Journal of Biological Chemistry. 272: 20456-62
Ke SH, Coombs GS, Tachias K, et al. (1997) Distinguishing the specificities of closely related proteases. Role of P3 in substrate and inhibitor discrimination between tissue-type plasminogen activator and urokinase. The Journal of Biological Chemistry. 272: 16603-9
Corey DR, Coombs GS, Bergstrom RC, et al. (1997) 178 Targeting proteolysis to non-physiological protein substrates Fibrinolysis and Proteolysis. 11: 51
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