Sean B. Joseph

Affiliations: 
Genomics Institute of the Novartis Research Foundation 
Area:
Drug Discovery and Development
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"Sean Joseph"
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Children

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Daniela Bumbaca grad student 2013-2016 Genentech, Inc.
Scott McDonnel research scientist 2012-2013 Pfizer Global Research & Development
Charles A. Boswell research scientist 2013-2016 Genentech, Inc.
Susan Crowell research scientist 2014-2016 Genentech, Inc.
Jitendra Shrawan Kanodia research scientist 2014-2016 Genentech, Inc.
Danielle N. Mandikian research scientist 2014-2016 Genentech, Inc. (Neurotree)
Ben Shen research scientist 2014-2016 Genentech, Inc.
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Publications

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Lee SC, Ma JSY, Kim MS, et al. (2021) A PSMA-targeted bispecific antibody for prostate cancer driven by a small-molecule targeting ligand. Science Advances. 7
Bakowski MA, Beutler N, Wolff KC, et al. (2021) Drug repurposing screens identify chemical entities for the development of COVID-19 interventions. Nature Communications. 12: 3309
Lear S, Pflimlin E, Zhou Z, et al. (2020) Engineering of a Potent, Long-Acting NPY2R Agonist for Combination with a GLP-1R Agonist as a Multi-Hormonal Treatment for Obesity. Journal of Medicinal Chemistry
Chin EN, Yu C, Vartabedian VF, et al. (2020) Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science (New York, N.Y.). 369: 993-999
Ardestani A, Li S, Annamalai K, et al. (2019) Neratinib protects pancreatic beta cells in diabetes. Nature Communications. 10: 5015
Bakowski MA, Shiroodi RK, Liu R, et al. (2019) Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections. Science Translational Medicine. 11
Mandikian D, Figueroa I, Oldendorp A, et al. (2018) Tissue Physiology of Cynomolgus Monkeys: Cross-Species Comparison and Implications for Translational Pharmacology. The Aaps Journal. 20: 107
Janes J, Young ME, Chen E, et al. (2018) The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis. Proceedings of the National Academy of Sciences of the United States of America. 115: 10750-10755
Mandikian D, Takahashi N, Lo AA, et al. (2018) Relative Target Affinities of T Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model. Molecular Cancer Therapeutics
Wang RE, Wang Y, Zhang Y, et al. (2016) Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant. Proceedings of the National Academy of Sciences of the United States of America. 113: 11501-11506
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