Sean B. Joseph

Affiliations: 
Genomics Institute of the Novartis Research Foundation 
Area:
Drug Discovery and Development
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"Sean Joseph"
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Children

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Daniela Bumbaca grad student 2013-2016 Genentech, Inc.
Scott McDonnel research scientist 2012-2013 Pfizer Global Research & Development
Charles A. Boswell research scientist 2013-2016 Genentech, Inc.
Susan Crowell research scientist 2014-2016 Genentech, Inc.
Jitendra Shrawan Kanodia research scientist 2014-2016 Genentech, Inc.
Danielle N. Mandikian research scientist 2014-2016 Genentech, Inc. (Neurotree)
Ben Shen research scientist 2014-2016 Genentech, Inc.
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Publications

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Lee SC, Ma JSY, Kim MS, et al. (2021) A PSMA-targeted bispecific antibody for prostate cancer driven by a small-molecule targeting ligand. Science Advances. 7
Bakowski MA, Beutler N, Wolff KC, et al. (2021) Drug repurposing screens identify chemical entities for the development of COVID-19 interventions. Nature Communications. 12: 3309
Lear S, Pflimlin E, Zhou Z, et al. (2020) Engineering of a Potent, Long-Acting NPY2R Agonist for Combination with a GLP-1R Agonist as a Multi-Hormonal Treatment for Obesity. Journal of Medicinal Chemistry
Chin EN, Yu C, Vartabedian VF, et al. (2020) Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science (New York, N.Y.). 369: 993-999
Olson KE, Namminga KL, Schwab AD, et al. (2020) Neuroprotective Activities of Long-Acting Granulocyte-Macrophage Colony-Stimulating Factor (mPDM608) in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Intoxicated Mice. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics
Chianelli D, Rucker PV, Roland J, et al. (2020) Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis (NASH). Journal of Medicinal Chemistry
Arnold SL, Conrad T, McNamara C, et al. (2020) Predicting the impact of infectious diarrhea pathophysiology on drug disposition The Faseb Journal. 34: 1-1
Johnson K, Woods A, Joseph S, et al. (2020) Development of KA34 as a cartilage regenerative therapy for Osteoarthritis Osteoarthritis and Cartilage. 28: S518
Pflimlin E, Zhou Z, Amso Z, et al. (2019) Engineering a Potent, Long-Acting, and Periphery-Restricted Oxytocin Receptor Agonist with Anorexigenic and Body Weight Reducing Effects. Journal of Medicinal Chemistry
Hernandez ED, Zheng L, Kim Y, et al. (2019) Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents. Hepatology Communications. 3: 1085-1097
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