Daniela Bumbaca

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2013-2016 PTPK Genentech Inc., Oceanside, CA, United States 
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"Daniela Bumbaca"
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Publications

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Deng R, Bumbaca D, Pastuskovas CV, et al. (2016) Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor. Mabs. 1-11
Zuchero YJ, Chen X, Bien-Ly N, et al. (2015) Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies. Neuron
Kinnunen HM, Sharma V, Contreras-Rojas LR, et al. (2015) A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components. Journal of Controlled Release : Official Journal of the Controlled Release Society. 214: 94-102
Uppal H, Doudement E, Mahapatra K, et al. (2015) Potential mechanisms for thrombocytopenia development with trastuzumab emtansine (T-DM1). Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 123-33
Kamath AV, Yip V, Gupta P, et al. (2014) Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice. Mabs. 6: 1631-7
Yu YJ, Atwal JK, Zhang Y, et al. (2014) Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Science Translational Medicine. 6: 261ra154
Boswell CA, Mundo EE, Ulufatu S, et al. (2014) Comparative physiology of mice and rats: radiometric measurement of vascular parameters in rodent tissues. Molecular Pharmaceutics. 11: 1591-8
Yip V, Palma E, Tesar DB, et al. (2014) Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor. Mabs. 6: 689-96
Bien-Ly N, Yu YJ, Bumbaca D, et al. (2014) Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants. The Journal of Experimental Medicine. 211: 233-44
Boswell CA, Marik J, Elowson MJ, et al. (2013) Enhanced tumor retention of a radiohalogen label for site-specific modification of antibodies. Journal of Medicinal Chemistry. 56: 9418-26
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