Jan Grunewald
Affiliations: | Genomics Institute of the Novartis Research Foundation |
Area:
Antibody-Drug Conjugates, Protein/Antibody Engineering, Conjugation Strategies, Genetic Code Expansion, Secondary Metabolite Engineering, Enzymology, Peptide ChemistryGoogle:
"Jan Grunewald"Mean distance: (not calculated yet)
Children
Sign in to add trainee| Huanfang Zhou | research assistant | Genomics Institute of the Novartis Research Foundation |
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Publications
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| Grünewald J, Brock A, Geierstanger BH. (2019) Site-Specific Antibody Labeling Using Phosphopantetheinyl Transferase-Catalyzed Ligation. Methods in Molecular Biology (Clifton, N.J.). 2012: 237-278 |
| Grunewald J, Jin Y, Vance J, et al. (2017) Optimization of an Enzymatic Antibody Drug Conjugation Approach based on CoA Analogs. Bioconjugate Chemistry |
| Grunewald J, Klock HE, Cellitti SE, et al. (2015) Efficient preparation of site-specific antibody-drug conjugates using phosphopantetheinyl transferases. Bioconjugate Chemistry |
| Venable JD, Steckler C, Ou W, et al. (2015) Isotope-Coded Labeling for Accelerated Protein Interaction Profiling Using MS. Analytical Chemistry. 87: 7540-4 |
| Chiu HP, Grünewald J, Hao X, et al. (2012) Simultaneous purification and site-specific modification of pyrroline-carboxy-lysine proteins. Chembiochem : a European Journal of Chemical Biology. 13: 364-6 |
| Gauba V, Grünewald J, Gorney V, et al. (2011) Loss of CD4 T-cell-dependent tolerance to proteins with modified amino acids. Proceedings of the National Academy of Sciences of the United States of America. 108: 12821-6 |
| Ou W, Uno T, Chiu HP, et al. (2011) Site-specific protein modifications through pyrroline-carboxy-lysine residues. Proceedings of the National Academy of Sciences of the United States of America. 108: 10437-42 |
| Cellitti SE, Ou W, Chiu HP, et al. (2011) D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine. Nature Chemical Biology. 7: 528-30 |
| Grünewald J, Tsao ML, Perera R, et al. (2008) Immunochemical termination of self-tolerance. Proceedings of the National Academy of Sciences of the United States of America. 105: 11276-80 |
| Kopp F, Mahlert C, Grünewald J, et al. (2006) Peptide macrocyclization: the reductase of the nostocyclopeptide synthetase triggers the self-assembly of a macrocyclic imine. Journal of the American Chemical Society. 128: 16478-9 |