Tetsuo Uno

Affiliations: 
GNF 
Area:
Protein medicinal chemistry
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"Tetsuo Uno"
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Parents

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Peter G. Schultz grad student 1990-1996 UC Berkeley
Peter G. Schultz research scientist 2001-2010 GNF
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Publications

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Pham GH, Ou W, Bursulaya B, et al. (2018) Tuning a Protein Labeling Reaction to Achieve Highly Site-Selective Lysine Conjugation. Chembiochem : a European Journal of Chemical Biology
Grunewald J, Jin Y, Vance J, et al. (2017) Optimization of an Enzymatic Antibody Drug Conjugation Approach based on CoA Analogs. Bioconjugate Chemistry
Michellys PY, Chen B, Jiang T, et al. (2015) Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors. Bioorganic & Medicinal Chemistry Letters
Grunewald J, Klock HE, Cellitti SE, et al. (2015) Efficient preparation of site-specific antibody-drug conjugates using phosphopantetheinyl transferases. Bioconjugate Chemistry
Grünewald J, Jones DH, Brock A, et al. (2014) Site-specific dual labeling of proteins by using small orthogonal tags at neutral pH. Chembiochem : a European Journal of Chemical Biology. 15: 1787-91
Thoma G, Blanz J, Bühlmayer P, et al. (2014) Syk inhibitors with high potency in presence of blood. Bioorganic & Medicinal Chemistry Letters. 24: 2278-82
Marsilje TH, Pei W, Chen B, et al. (2013) Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. Journal of Medicinal Chemistry. 56: 5675-90
Chiu HP, Grünewald J, Hao X, et al. (2012) Simultaneous purification and site-specific modification of pyrroline-carboxy-lysine proteins. Chembiochem : a European Journal of Chemical Biology. 13: 364-6
Ou W, Uno T, Chiu HP, et al. (2011) Site-specific protein modifications through pyrroline-carboxy-lysine residues. Proceedings of the National Academy of Sciences of the United States of America. 108: 10437-42
Cellitti SE, Ou W, Chiu HP, et al. (2011) D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine. Nature Chemical Biology. 7: 528-30
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