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Fleur M. Ferguson

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
Chemical Biology
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"Fleur Ferguson"
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Parents

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Alan C. Spivey research assistant 2009-2010 Imperial College London
Christopher Abell grad student 2010-2014 Cambridge
Alessio Ciulli grad student 2010-2014 University of Cambridge, United Kingdom
Nathanael Gray post-doc 2015- Harvard Medical School/Dana-Farber Cancer Institute

Children

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Nathan L Tran grad student 2021-2026 UCSD

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Publications

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Tran NL, Leconte GA, Ferguson FM. (2022) Targeted Protein Degradation: Design Considerations for PROTAC Development. Current Protocols. 2: e611
Silva MC, Nandi G, Donovan KA, et al. (2022) Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy. Frontiers in Cellular Neuroscience. 16: 801179
Tao AJ, Gadbois GE, Buczynski SA, et al. (2022) Targeted protein degradation: Emerging concepts and protein state-specific targeting principles. Current Opinion in Chemical Biology. 67: 102114
Seong BKA, Dharia NV, Lin S, et al. (2021) TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma. Cancer Cell
Carli ALE, Afshar-Sterle S, Rai A, et al. (2021) Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells. Proteomics. e2000098
Jiang B, Jiang J, Kaltheuner IH, et al. (2021) Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma. European Journal of Medicinal Chemistry. 221: 113481
Donovan KA, Ferguson FM, Bushman JW, et al. (2020) Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell
Nabet B, Ferguson FM, Seong BKA, et al. (2020) Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nature Communications. 11: 4687
Ferguson FM, Liu Y, Harshbarger W, et al. (2020) Correction to "Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6-benzo[]pyrimido[5,4-][1,4]diazepin-6-one Scaffold". Journal of Medicinal Chemistry
Liu Y, Ferguson FM, Li L, et al. (2020) Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing. Cell Chemical Biology
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