Christopher Michael Browne

Harvard Medical School/Dana-Farber Cancer Institute, Boston, MA, United States 
Proteomics, Covalent Inhibitors, Kinases
"Christopher Browne"
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Andrew J. Link grad student 2007-2013 Vanderbilt
 (Genetic and biochemical analysis of the interaction between the yeast fatty acid synthesis enzyme ybr159w and the translation initiation complex eIF2B.)
Nathanael Gray post-doc 2014- Harvard Medical School/Dana-Farber Cancer Institute
Jarrod A. Marto post-doc 2014- Harvard Medical School/Dana-Farber Cancer Institute
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Dubiella C, Pinch BJ, Koikawa K, et al. (2021) Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Nature Chemical Biology
Sun M, Shen B, Li W, et al. (2020) A time-resolved cryo-EM Study of S. cerevisiae 80S Ribosome Protein Composition in Response to a Change in Carbon Source. Proteomics. e2000125
Pinch BJ, Doctor ZM, Nabet B, et al. (2020) Identification of a potent and selective covalent Pin1 inhibitor. Nature Chemical Biology
Sivakumaren SC, Shim H, Zhang T, et al. (2020) Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chemical Biology
Link AJ, Niu X, Weaver CM, et al. (2020) Targeted identification of protein interactions in eukaryotic mRNA translation. Proteomics. e1900177
Rao S, Gurbani D, Du G, et al. (2019) Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. Cell Chemical Biology
Ferguson FM, Doctor ZM, Ficarro SB, et al. (2019) Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chemical Biology
Pinch B, Doctor Z, Browne CM, et al. (2019) Abstract 2757: Discovery and characterization of covalent Pin1 inhibitors targeted to an active site cysteine Cancer Research. 79: 2757-2757
Browne CM, Jiang B, Ficarro SB, et al. (2018) A Chemoproteomic Strategy for Direct and Proteome-wide Covalent Inhibitor Target-site Identification. Journal of the American Chemical Society
Gerbasi VR, Browne CM, Samir P, et al. (2018) Critical Role for Saccharomyces cerevisiae Asc1p in Translational Initiation at Elevated Temperatures. Proteomics. e1800208
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