Liv H. Johannessen, Ph.D.

2007-2012 Cancer Inflammation Program National Cancer Institute at Frederick, MD 21702 USA, Frederick, MD, United States 
 2012- BCMP Harvard University, Cambridge, MA, United States 
CDKs, Transcription, Immunology
"Liv Johannessen"
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Arnett A, Moo KG, Flynn KJ, et al. (2021) The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4 T cells via a novel CDK8-GATA3-FOXP3 pathway. Molecular and Cellular Biology. MCB0008521
Johannessen L, Ke N, Sawant P, et al. (2020) Activity of SY-5609, an oral, noncovalent, potent, and selective CDK7 inhibitor, in preclinical models of colorectal cancer. Journal of Clinical Oncology. 38: 3585-3585
Hu S, Marineau JJ, Rajagopal N, et al. (2019) Discovery and characterization of SY-1365, a selective, covalent inhibitor of CDK7. Cancer Research
Ke N, Johannessen L, Rajagopal N, et al. (2019) Abstract 4409: Prospective identification of RB pathway alterations predict response to SY-1365, a selective CDK7 inhibitor, in a panel of high-grade serous ovarian cancer (HGSOC) patient derived xenograft (PDX) models Cancer Research. 79: 4409-4409
Johannessen LH, Hu S, Ke N, et al. (2019) Abstract C091: Preclinical evaluation of PK, PD, and antitumor activity of the oral, non-covalent, potent and highly selective CDK7 inhibitor, SY-5609, provides rationale for clinical development in multiple solid tumor indications Molecular Cancer Therapeutics. 18
Hatcher JM, Wang ES, Johannessen L, et al. (2018) Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8. Acs Medicinal Chemistry Letters. 9: 540-545
Konstantinopoulos PA, Hodgson G, Rajagopal N, et al. (2018) Abstract 1525: SY-1365, a selective CDK7 inhibitor, exhibits potent antitumor activity against ovarian cancer models in vitro and in vivo Cancer Research. 78: 1525-1525
Johannessen L, Sundberg TB, O'Connell DJ, et al. (2017) Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nature Chemical Biology
Sundberg TB, Liang Y, Wu H, et al. (2016) Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function In Vivo. Acs Chemical Biology
Tan L, Akahane K, McNally R, et al. (2015) Development of Selective Covalent JAK3 Inhibitors. Journal of Medicinal Chemistry
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