Hannah Woodward
Affiliations: | The Institute of Cancer Research |
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| Pierrat OA, Liu M, Collie GW, et al. (2022) Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays. Scientific Reports. 12: 18633 |
| Zhao Y, Mahy W, Willis NJ, et al. (2022) Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chemical Neuroscience |
| Willis NJ, Mahy W, Sipthorp J, et al. (2022) Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. Journal of Medicinal Chemistry |
| Bayle ED, Svensson F, Atkinson BN, et al. (2021) Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling. Journal of Medicinal Chemistry |
| Mahy W, Willis NJ, Zhao Y, et al. (2020) 5-Phenyl-1,3,4-oxadiazol-2(3)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit. Journal of Medicinal Chemistry |
| Mahy W, Patel M, Steadman D, et al. (2020) Screening of a custom-designed acid fragment library identifies 1-phenylpyrroles and 1-phenylpyrrolidines as inhibitors of Notum carboxylesterase activity. Journal of Medicinal Chemistry |
| Bellenie BR, Cheung KJ, Varela A, et al. (2020) Achieving Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders. Journal of Medicinal Chemistry |
| Anderhub SJ, Mak GW, Gurden MD, et al. (2019) High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers. Molecular Cancer Therapeutics. 18: 1696-1707 |
| Woodward HL, Innocenti P, Cheung KJ, et al. (2018) Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722). Journal of Medicinal Chemistry |
| Faisal A, Mak GW, Gurden MD, et al. (2017) Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy. British Journal of Cancer |