☰ Chemistry Tree

David Mendel

Affiliations:

1993-

Chemistry

University of California, Berkeley, Berkeley, CA

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Parents

Peter B. Dervan	grad student	1983-1989	Caltech
Peter G. Schultz	post-doc	1989-1992	UC Berkeley

Children

Collaborators

Marvin J. Miller	collaborator		Notre Dame
William L. Scott	collaborator		IUPUI
Peter Wipf	collaborator		University of Pittsburgh
(Co-mentor to Dr? Raffaele Colombo)

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Publications

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Colombo R, Wang Z, Han J, et al. (2016) Total Synthesis and Biological Evaluation of Tubulysin Analogs. The Journal of Organic Chemistry
Nguyen H, Allali-Hassani A, Antonysamy S, et al. (2015) LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. The Journal of Biological Chemistry. 290: 13641-53
Burkholder TP, Clayton JR, Rempala ME, et al. (2012) Discovery of LY2457546: A multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model Investigational New Drugs. 30: 936-949
Lin W, Virga KG, Kim KH, et al. (2009) Diastereoselective synthesis of a spironoraristeromycin using an acylnitroso Diels-Alder reaction. The Journal of Organic Chemistry. 74: 5941-6
Engle SK, Jordan WH, Pritt ML, et al. (2009) Qualification of cardiac troponin I concentration in mouse serum using isoproterenol and implementation in pharmacology studies to accelerate drug development. Toxicologic Pathology. 37: 617-28
Lin W, Gupta A, Kim KH, et al. (2009) Syntheses of new spirocarbocyclic nucleoside analogs using iminonitroso Diels-Alder reactions. Organic Letters. 11: 449-52
Mendel D, Marquart AL, Joseph S, et al. (2007) Anthranilamide inhibitors of factor Xa. Bioorganic & Medicinal Chemistry Letters. 17: 4832-6
Engler TA, Malhotra S, Burkholder TP, et al. (2005) The development of potent and selective bisarylmaleimide GSK3 inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 899-903
Engler TA, Henry JR, Malhotra S, et al. (2004) Substituted 3-imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as highly selective and potent inhibitors of glycogen synthase kinase-3. Journal of Medicinal Chemistry. 47: 3934-7
Hu J, Cwi CL, Smiley DL, et al. (2003) Design and synthesis of statine-containing BACE inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 4335-9

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