Jaebong Jang, Ph D

Harvard Medical School/Dana-Farber Cancer Institute, Boston, MA, United States 
"Jaebong Jang"
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Jang H, Park Y, Jang J. (2022) Serum and glucocorticoid-regulated kinase 1: Structure, biological functions, and its inhibitors. Frontiers in Pharmacology. 13: 1036844
Beyett TS, To C, Heppner DE, et al. (2022) Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors. Nature Communications. 13: 2530
To C, Beyett TS, Jang J, et al. (2022) An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer. Nature Cancer
Gero TW, Heppner DE, Beyett TS, et al. (2022) Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC. Bioorganic & Medicinal Chemistry Letters. 128718
Son J, Jang J, Beyett TS, et al. (2022) A novel HER2-selective kinase inhibitor is effective in HER2 mutant and amplified non-small cell lung cancer. Cancer Research
Jang J, To C, De Clercq DJH, et al. (2020) Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations. Angewandte Chemie (International Ed. in English)
De Clercq DJH, Heppner DE, To C, et al. (2019) Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors. Acs Medicinal Chemistry Letters. 10: 1549-1553
Lian W, Jang J, Potisopon S, et al. (2019) Correction to Discovery of Immunologically Inspired Small Molecules That Target the Viral Envelope Protein. Acs Infectious Diseases
To C, Jang J, Chen T, et al. (2019) Single and dual targeting of mutant EGFR with an allosteric inhibitor. Cancer Discovery
Pitts J, Hsia CY, Lian W, et al. (2019) Identification of small molecule inhibitors targeting the Zika virus envelope protein. Antiviral Research
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