Baishan Jiang, Ph.D

2015- Harvard Medical School/Dana-Farber Cancer Institute, Boston, MA, United States 
"Baishan Jiang"
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Ye M, Fang Y, Chen L, et al. (2024) Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability. Nature Communications. 15: 2377
Kumarasamy V, Gao Z, Zhao B, et al. (2023) PROTAC-mediated CDK degradation differentially impacts cancer cell cycles due to heterogeneity in kinase dependencies. British Journal of Cancer
Koide E, Mohardt ML, Doctor ZM, et al. (2023) Development and characterization of selective FAK inhibitors and PROTACs with in vivo activity. Chembiochem : a European Journal of Chemical Biology. e202300141
Gao Y, Jiang B, Kim H, et al. (2023) Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions. Journal of Medicinal Chemistry
Jiang B, Weinstock DM, Donovan KA, et al. (2023) ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas. Cell Chemical Biology. 30: 383-393.e6
Gao X, Wu Y, Chick JM, et al. (2023) Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance. Cell Reports. 42: 112314
Li Q, Jiang B, Guo J, et al. (2021) INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors. Cancer Discovery
Deng J, Thennavan A, Dolgalev I, et al. (2021) ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer. Nature Cancer. 2: 503-514
Jiang B, Jiang J, Kaltheuner IH, et al. (2021) Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma. European Journal of Medicinal Chemistry. 221: 113481
Jiang B, Gao Y, Che J, et al. (2021) Discovery and resistance mechanism of a selective CDK12 degrader. Nature Chemical Biology
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