Peter A. Smith

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2005-2011 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
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Publications

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Walsh SI, Peters DS, Smith PA, et al. (2018) The inhibition of protein secretion in and sub-MIC effects of arylomycin antibiotics. Antimicrobial Agents and Chemotherapy
Smith PA, Koehler MFT, Girgis HS, et al. (2018) Optimized arylomycins are a new class of Gram-negative antibiotics. Nature. 561: 189-194
Rodriguez RA, Barrios Steed D, Kawamata Y, et al. (2014) Axinellamines as broad-spectrum antibacterial agents: scalable synthesis and biology. Journal of the American Chemical Society. 136: 15403-13
Liu J, Smith PA, Steed DB, et al. (2013) Efforts toward broadening the spectrum of arylomycin antibiotic activity. Bioorganic & Medicinal Chemistry Letters. 23: 5654-9
Smith PA, Romesberg FE. (2012) Mechanism of action of the arylomycin antibiotics and effects of signal peptidase I inhibition. Antimicrobial Agents and Chemotherapy. 56: 5054-60
Liu J, Luo C, Smith PA, et al. (2011) Synthesis and characterization of the arylomycin lipoglycopeptide antibiotics and the crystallographic analysis of their complex with signal peptidase. Journal of the American Chemical Society. 133: 17869-77
Roberts TC, Schallenberger MA, Liu J, et al. (2011) Initial efforts toward the optimization of arylomycins for antibiotic activity. Journal of Medicinal Chemistry. 54: 4954-63
Roberts TC, Smith PA, Romesberg FE. (2011) Synthesis and biological characterization of arylomycin B antibiotics. Journal of Natural Products. 74: 956-61
Smith PA, Powers ME, Roberts TC, et al. (2011) In vitro activities of arylomycin natural-product antibiotics against Staphylococcus epidermidis and other coagulase-negative staphylococci. Antimicrobial Agents and Chemotherapy. 55: 1130-4
Powers ME, Smith PA, Roberts TC, et al. (2011) Type I signal peptidase and protein secretion in Staphylococcus epidermidis. Journal of Bacteriology. 193: 340-8
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