Shawn Walsh

2015- Scripps Research Institute, La Jolla, La Jolla, CA, United States 
"Shawn Walsh"
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Tan YX, Peters DS, Walsh SI, et al. (2020) Initial Analysis of the Arylomycin D Antibiotics. Journal of Natural Products
Walsh SI, Peters DS, Smith PA, et al. (2018) The inhibition of protein secretion in and sub-MIC effects of arylomycin antibiotics. Antimicrobial Agents and Chemotherapy
Yeh CH, Walsh SI, Craney A, et al. (2018) Optimization of a β-Lactam Scaffold for Antibacterial Activity via the Inhibition of Bacterial Type I Signal Peptidase. Acs Medicinal Chemistry Letters. 9: 376-380
Walsh SI, Craney A, Romesberg FE. (2016) Not just an antibiotic target: Exploring the role of type I signal peptidase in bacterial virulence. Bioorganic & Medicinal Chemistry
Tang H, Zhu Y, Teumelsan N, et al. (2016) Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure. Acs Medicinal Chemistry Letters. 7: 697-701
Walsh SP, Shahripour A, Tang H, et al. (2016) Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation. Bioorganic & Medicinal Chemistry Letters
Parker DL, Walsh S, Li B, et al. (2015) Rapid development of two factor IXa inhibitors from hit to lead. Bioorganic & Medicinal Chemistry Letters. 25: 2321-5
Tang H, de Jesus RK, Walsh SP, et al. (2013) Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one. Bioorganic & Medicinal Chemistry Letters. 23: 5829-32
An C, Jurica JA, Walsh SP, et al. (2013) Total synthesis of (+)-irciniastatin A (a.k.a. psymberin) and (-)-irciniastatin B. The Journal of Organic Chemistry. 78: 4278-96
Tang H, Walsh SP, Yan Y, et al. (2012) Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics. Acs Medicinal Chemistry Letters. 3: 367-72
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