David H. Ives, Ph.D.

Affiliations: 
Biochemistry Ohio State University, Columbus, Columbus, OH 
Area:
deoxynucleoside kinases, nucleoside phosphotransferase
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"David Ives"
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Parents

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Cyrus Paine Barnum, Jr grad student 1960 UMN
 (A Kinetic Evaluation, Employing Radiophosphorus, of the Synthesis and Metabolic Stability of DNA in Regenerating Rat Liver)
Van R. Potter post-doc 1960-1962 UW Madison
 (thymidine kinase, pyrimidine metabolism)

Children

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Paul R. Gardner research assistant 1982-1984 Ohio State
Douglas C. Prasher grad student 1979 Ohio State
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Publications

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Park I, Ives DH. (2002) Mutations within the putative active site of heterodimeric deoxyguanosine kinase block the allosteric activation of the deoxyadenosine kinase subunit. Journal of Biochemistry and Molecular Biology. 35: 244-7
Lunato AJ, Wang J, Woollard JE, et al. (1999) Synthesis of 5-(carboranylalkylmercapto)-2'-deoxyuridines and 3-(carboranylalkyl)thymidines and their evaluation as substrates for human thymidine kinases 1 and 2. Journal of Medicinal Chemistry. 42: 3378-89
Soloway AH, Zhuo JC, Rong FG, et al. (1999) Identification, development, synthesis and evaluation of boron-containing nucleosides for neutron capture therapy Journal of Organometallic Chemistry. 581: 150-155
Guo S, Ives DH. (1998) Functional assignment by Chimera construction of the domain affecting heterotropic activation of deoxyadenosine kinase from Lactobacillus acidophilus R-26. The Journal of Biological Chemistry. 273: 26624-30
Ives DH, Ikeda S. (1998) Life on the salvage path: the deoxynucleoside kinase of Lactobacillus acidophilus R-26. Progress in Nucleic Acid Research and Molecular Biology. 59: 205-55
Guo S, Ma N, Ives DH. (1997) cis-Active Ras G2-like sequence implicated in the heterotropic activation of the deoxyadenosine kinase of Lactobacillus acidophilus R-26. The Journal of Biological Chemistry. 272: 6890-7
Rong FG, Soloway AH, Ikeda S, et al. (1997) Synthesis and biochemical activity of hydrophilic carborane-containing pyrimidine nucleosides as potential agents for DNA incorporation and BNCT Nucleosides and Nucleotides. 16: 379-401
Ma N, Ikeda S, Guo S, et al. (1996) Deoxycytidine kinase and deoxyguanosine kinase of Lactobacillus acidophilus R-26 are colinear products of a single gene. Proceedings of the National Academy of Sciences of the United States of America. 93: 14385-90
Guo S, Ma N, Ives DH. (1996) Ras G2-like sequence implicated in the subunit-subunit interaction of heterodimeric deoxyadenosine kinase/deoxyguanosine kinase of lactobacilll's acwophilus R-26 Faseb Journal. 10: A1263
Park I, Ives DH. (1995) Kinetic mechanism and end-product regulation of deoxyguanosine kinase from beef liver mitochondria. Journal of Biochemistry. 117: 1058-61
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