Jason C. Wong

Affiliations: 
2004 Harvard University, Cambridge, MA, United States 
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"Jason Wong"
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Stuart L. Schreiber grad student 2004 Harvard
 (Discovery of small molecule probes for chemical genetics using biased and unbiased diversity-oriented organic synthesis.)
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Publications

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Lin X, Chen W, Qiu Z, et al. (2015) Design and synthesis of orally bioavailable aminopyrrolidinone histone deacetylase 6 inhibitors. Journal of Medicinal Chemistry. 58: 2809-20
Tang G, Wong JC, Zhang W, et al. (2014) Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors. Journal of Medicinal Chemistry. 57: 8026-34
Zhang Z, Lin Z, Zhou Z, et al. (2014) Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction. Acs Medicinal Chemistry Letters. 5: 993-8
Shen Q, Wu JZ, Wong JC. (2013) Potential drug interventions for diabetic retinopathy. Drug Discovery Today. 18: 1334-41
Haggarty SJ, Clemons PA, Wong JC, et al. (2004) Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors. Combinatorial Chemistry & High Throughput Screening. 7: 669-76
Wong JC, Sternson SM, Louca JB, et al. (2004) Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes. Chemistry & Biology. 11: 1279-91
Koeller KM, Haggarty SJ, Perkins BD, et al. (2003) Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. Chemistry & Biology. 10: 397-410
Haggarty SJ, Koeller KM, Wong JC, et al. (2003) Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays. Chemistry & Biology. 10: 383-96
Wong JC, Hong R, Schreiber SL. (2003) Structural biasing elements for in-cell histone deacetylase paralog selectivity. Journal of the American Chemical Society. 125: 5586-7
Haggarty SJ, Koeller KM, Wong JC, et al. (2003) Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proceedings of the National Academy of Sciences of the United States of America. 100: 4389-94
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