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Whocely V. de Castro, Ph.D.

Affiliations: 
2006 University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Pharmacy
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Veronika Butterweck grad student 2006 UF Gainesville
 (Effect of grapefruit juice on P -glycoprotein activity.)

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do Nascimento SB, de Lima Nascimento M, de Araújo LL, et al. (2020) Evaluation of the effects of Maytenus ilicifolia on the activities of cytochrome P450 3A and P-glycoprotein. Current Drug Metabolism
Guimarães DSM, de Sousa Luz LS, do Nascimento SB, et al. (2019) Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle: Mode of action, mutagenicity profile, and Caco-2 cell-based permeability. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 105015
Brillault J, De Castro WV, Couet W. (2010) Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model. Antimicrobial Agents and Chemotherapy. 54: 543-5
Brillault J, De Castro WV, Harnois T, et al. (2009) P-glycoprotein-mediated transport of moxifloxacin in a Calu-3 lung epithelial cell model. Antimicrobial Agents and Chemotherapy. 53: 1457-62
de Castro WV, Mertens-Talcott S, Derendorf H, et al. (2008) Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats. Journal of Agricultural and Food Chemistry. 56: 4840-5
de Castro WV, Mertens-Talcott S, Derendorf H, et al. (2007) Grapefruit juice-drug interactions: Grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells. Journal of Pharmaceutical Sciences. 96: 2808-17
Mertens-Talcott SU, De Castro WV, Manthey JA, et al. (2007) Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells. Journal of Agricultural and Food Chemistry. 55: 2563-8
Salvador MJ, Ferreira EO, Mertens-Talcott SU, et al. (2006) Isolation and HPLC quantitative analysis of antioxidant flavonoids from Alternanthera tenella Colla Zeitschrift Fur Naturforschung - Section C Journal of Biosciences. 61: 19-25
De Castro WV, Mertens-Talcott S, Rubner A, et al. (2006) Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studies. Journal of Agricultural and Food Chemistry. 54: 249-55
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